22649-28-1

22649-28-1 - Names and Identifiers

Name	2H-chromene-3-carboxylic acid
Synonyms	15N]-L-Cysteine TIMTEC-BB SBB010135 IFLAB-BB F0918-2550 RARECHEM AL BE 1212 2H-chromene-3-carboxylate 2H-chromene-3-carboxylic acid 2H-CHROMENE-3-CARBOXYLIC ACID 2H-1-Benzopyran-3-carboxylicacid 2H-1-Benzopyran-3-carboxylic acid 2H-Chromene-3-carboxylic acid, 3-Carboxy-2H-chromene
CAS	22649-28-1
InChI	InChI=1/C10H8O3/c11-10(12)8-5-7-3-1-2-4-9(7)13-6-8/h1-5H,6H2,(H,11,12)/p-1

22649-28-1 - Physico-chemical Properties

Molecular Formula	C10H8O3
Molar Mass	176.17
Density	1.346±0.06 g/cm3(Predicted)
Melting Point	184-186°C
Boling Point	327.3±41.0 °C(Predicted)
Flash Point	134.8°C
Vapor Presure	8.29E-05mmHg at 25°C
pKa	3.88±0.20(Predicted)
Storage Condition	2-8°C

22649-28-1 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R51 - Toxic to aquatic organisms R36 - Irritating to the eyes R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note	Harmful
Hazard Class	IRRITANT

22649-28-1 - Introduction

2H-chromene-3-carboxylic acid is an organic compound with a special structure, and its molecular formula is C10H6O3.

Nature:
2H-chromene-3-carboxylic acid is a white crystalline solid, stable at room temperature and pressure. It has low solubility and is soluble in polar solvents such as ethanol, dimethyl sulfoxide, etc., but has low solubility in non-polar solvents. It has weak acidity and can react with alkali to form the corresponding salt.

Use:
2H-chromene-3-carboxylic acid is an important organic synthesis intermediate, which is widely used in the synthesis of drugs and pesticides. Its special structure makes it have great value in pharmaceutical and agronomic research, and can be used as a key synthetic raw material for anti-cancer drugs, antibacterial agents and pesticides.

Method:
The preparation method of 2H-chromene-3-carboxylic acid is often realized by organic synthesis reaction. One common method is to react benzopyran with sulfur dioxide (SO2) in the presence of hydrochloric acid to produce the corresponding sulfonic acid. The sulfonic acid is then converted to 2H-chromene-3-carboxylic acid by acidic or basic hydrolysis.

Safety Information:
2H-chromene-3-carboxylic acid is generally a low-toxic substance under laboratory conditions, but as an organic compound, it is still necessary to pay attention to safe operation. It can be irritating to the eyes and skin, so use appropriate protective measures such as lab gloves, goggles, and lab benches. In addition, avoid inhalation of its dust or solution, and use and store in a well-ventilated environment. Local regulations and safety guidelines should be followed when handling and disposing of the compound. In case of accidental spilling or inhalation, seek medical attention immediately.

Last Update：2024-04-09 20:52:54