232271-19-1
(S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid
CAS: 232271-19-1
Molecular Formula: C24H21Cl2NO5
232271-19-1 - Names and Identifiers
| Name | (S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid |
| Synonyms | TR14035 MDK1191 TR 14035 TR-14035 MDK-1191 N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine (S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid (S)-2-(2,6-DichlorobenzaMido)-3-(2',6'-diMethoxy-[1,1'-biphenyl]-4-yl)propanoic acid (alphaS)-alpha-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy-[1,1'-biphenyl]-4-propanoic acid |
| CAS | 232271-19-1 |
232271-19-1 - Physico-chemical Properties
| Molecular Formula | C24H21Cl2NO5 |
| Molar Mass | 474.33 |
| Density | 1.333 |
| Boling Point | 604.0±55.0 °C(Predicted) |
| pKa | 3.53±0.10(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD09970400 |
| In vitro study | TR14035 blocks adhesion of RPMI-8866 cells to MAdCAM-Ig by 100% at 1μM, with an approximate IC 50 of 0.01μM. |
| In vivo study | TR-14035 (3 mg/kg; i.g.) produces a significant decrease of the airways hyper-responsiveness to 5-hydroxytryptamine (5-HT) in an experimental model of allergic asthma in Brown Norway rats. TR-14035 exhibits plasma decreased with half-lives of 0.28 h (3 mg/kg for i.v.) and 0.39 h (10 mg/kg for i.g.), and the oral bioavailability (F) is 17%. Animal Model: Male Brown Norway rats (250-300 g) Dosage: 3 mg/kg Administration: Oral gavage, 1 h before and 3 h after antigen challenge Result: Suppressed antigen-induced airway hyper-responsiveness and inflammation. Animal Model: Male Sprague-Dawley rats (250-320 g) Dosage: 3 mg/ kg for i.v.; 10 mg/kg for i.g. Administration: Intravenous injection and oral gavage Result: T 1/2 (1.88 h for i.v.; 3.42 h for i.g.), F (17%). |
232271-19-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.108 ml | 10.541 ml | 21.082 ml |
| 5 mM | 0.422 ml | 2.108 ml | 4.216 ml |
| 10 mM | 0.211 ml | 1.054 ml | 2.108 ml |
| 5 mM | 0.042 ml | 0.211 ml | 0.422 ml |
Last Update：2024-01-02 23:10:35
232271-19-1 - Reference Information
| biological activity | TR-14035 (SB 683698, MDK-1191) is a alpha4beta (α4β) integrin double-effect antagonist, and the IC50 values for alpha4beta7 (α4β7) and alpha4beta1 (α4β1) are 7 nM and 87 nM respectively. |
| target | TargetValue α4β7 (cell-free say) 7 nM α4β1 (cell-free say) 87 nM |
| Target | Value |
| α4β7 (Cell-free assay) | 7 nM |
| α4β1 (Cell-free assay) | 87 nM |
| in vitro study | TR14035 blocks adhesion of RPMI-8866 cells to MAdCAM-Ig by 100% at 1 μM, with an approximate IC 50 of 0.01 μM. |
| in vivo study | TR-14035 (3 mg/kg; I. g.) produces a significant decrease of the airways hyper-responsiveness to 5-hydroxytryptamine (5-HT) in an experimental model of allergic asthma in brown norway rats. TR-14035 exhibits plasma decreased with half-living of 0.28 h (3 mg/kg for I. v.) and 0.39 h (10 mg/kg for I. g.), and the oral bioavailability (F) is 17%. Animal Model: male Brown Norway Rats (250-300 g) Dosage: 3 mg/kg Administration: Oral gavage, 1 h before and 3 h after antigen challenge Result: Suppressed antigen-induced airway hyper-responsiveness and inflammation. Animal Model: Male Sprague-Dawley Rats (250-320g) Dosage: 3 mg/kg for I. v.; 10 mg/kg for I. g. Administration: intravenous injection and oral gavage result: t 1/2 (1.88 h for I. v.; 3.42 h for I. g.), F (17%). |
| Animal Model: | Male Brown Norway rats (250-300 g) Male Sprague-Dawley rats (250-320 g) |
| Dosage: | 3 mg/kg 3 mg/ kg for i.v.; 10 mg/kg for i.g. |
| Administration: | Oral gavage, 1 h before and 3 h after antigen challenge Intravenous injection and oral gavage |
| Result: | Suppressed antigen-induced airway hyper-responsiveness and inflammation. T 1/2 (1.88 h for i.v.; 3.42 h for i.g.), F (17%). |
Last Update：2024-04-10 22:29:15
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Product Name: (S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid Visit Supplier Webpage Request for quotationCAS: 232271-19-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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