2328073-61-4
ZT-12-037-01
CAS: 2328073-61-4
Molecular Formula: C21H31N5O2
2328073-61-4 - Names and Identifiers
| Name | ZT-12-037-01 |
| Synonyms | ZT-12-037-01 2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]- |
| CAS | 2328073-61-4 |
2328073-61-4 - Physico-chemical Properties
| Molecular Formula | C21H31N5O2 |
| Molar Mass | 385.5 |
| Solubility | DMSO : 8.33 mg/mL (21.61 mM; Need ultrasonic) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | ZT-12-037-01 treatment was effective in inhibiting NRAS phosphorylation. ZT-12-037-01 is a competitive inhibitor of ATP and is effective in inhibiting melanocyte colony formation, proliferation and tumor formation driven by mutation NRAS-STK19. The pro-apoptotic activity of ZT-12-037-01 was significantly enhanced in cells expressing oncogenic NRAS. |
| In vivo study | ZT-12-037-01 is a highly effective STK19 inhibitor with low toxicity in vivo. In a SK-MEL-2 xenograft model (bearing NRAS. |
2328073-61-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.594 ml | 12.97 ml | 25.94 ml |
| 5 mM | 0.519 ml | 2.594 ml | 5.188 ml |
| 10 mM | 0.259 ml | 1.297 ml | 2.594 ml |
| 5 mM | 0.052 ml | 0.259 ml | 0.519 ml |
Last Update：2024-01-02 23:10:35
2328073-61-4 - Introduction
ZT-12-037-01 is a compound whose properties are as follows:
Nature:
-Appearance: The ZT-12-037-01 is white crystalline powder.
-Solubility: ZT-12-037-01 soluble in organic solvents, such as ethanol and dimethylformamide.
Use:
ZT-12-037-01 have a variety of applications in the chemical field, including:
-Catalyst: It can be used as a catalyst for redox reactions.
-Hybrid material: It can be used to prepare new hybrid materials, such as optoelectronic materials and electronic materials.
Preparation Method:
The method of preparing the ZT-12-037-01 is as follows:
1. Through the synthesis reaction, the appropriate raw materials and catalyst or solvent reaction.
2. The reaction mixture was purified by crystallization and drying, and finally the ZT-12-037-01 was obtained.
Safety Information:
-Wear personal protective equipment, such as safety glasses and gloves, to avoid contact with skin and eyes.
-Avoid inhaling its dust and operate in a well-ventilated place.
-If skin contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
-Store the ZT-12-037-01 in a dry, cool, dark place, away from fire and combustibles.
Nature:
-Appearance: The ZT-12-037-01 is white crystalline powder.
-Solubility: ZT-12-037-01 soluble in organic solvents, such as ethanol and dimethylformamide.
Use:
ZT-12-037-01 have a variety of applications in the chemical field, including:
-Catalyst: It can be used as a catalyst for redox reactions.
-Hybrid material: It can be used to prepare new hybrid materials, such as optoelectronic materials and electronic materials.
Preparation Method:
The method of preparing the ZT-12-037-01 is as follows:
1. Through the synthesis reaction, the appropriate raw materials and catalyst or solvent reaction.
2. The reaction mixture was purified by crystallization and drying, and finally the ZT-12-037-01 was obtained.
Safety Information:
-Wear personal protective equipment, such as safety glasses and gloves, to avoid contact with skin and eyes.
-Avoid inhaling its dust and operate in a well-ventilated place.
-If skin contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
-Store the ZT-12-037-01 in a dry, cool, dark place, away from fire and combustibles.
Last Update：2024-04-09 15:16:35
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Product Name: ZT-12-037-01 Visit Supplier Webpage Request for quotation
CAS: 2328073-61-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 2328073-61-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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