23541-50-6
Daunorubicin hydrochloride
CAS: 23541-50-6
Molecular Formula: C34H36ClN3O10
23541-50-6 - Names and Identifiers
| Name | Daunorubicin hydrochloride |
| Synonyms | daunoblastin Daunorubicin hydrochloride |
| CAS | 23541-50-6 |
| EINECS | 245-723-4 |
23541-50-6 - Physico-chemical Properties
| Molecular Formula | C34H36ClN3O10 |
| Molar Mass | 682.12 |
| Melting Point | 190°C (dec) |
| Storage Condition | 2-8℃ |
| Use | Daunorubicin Hydrochloride, as a commonly used drug in the treatment of acute myeloid leukemia, acute lymphocytic leukemia, acute monocytic leukemia and other diseases in the Department of Hematology, is the first generation of anthracycline antibiotics, in addition to the clinical for the treatment of acute and chronic leukemia can also be combined with prednisone, cytarabine or vinblastine and other drugs to increase its anti-tumor effect. |
23541-50-6 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R40 - Limited evidence of a carcinogenic effect R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
23541-50-6 - A Daunorubicin Hydrochloride for Injection
from Palm Bridge research
Application (patent) number:
CN201410625648.8
application date:
2014-11-08
Public/Announcement Number:
CN104434818B
Public/announcement date:
2017.08.08
applicant (patent):
Shandong New Times Pharmaceutical Co., Ltd.
inventor:
Zhao Zhiquan , , statics , Deng Rong
National and provincial code:
CN371325
Abstract:
The invention belongs to the technical field of Western medicine preparations, and in particular provides a Daunorubicin Hydrochloride for Injection freeze-dried powder injection and a preparation method thereof. The lyophilized powder injection is prepared from Daunorubicin Hydrochloride, mannitol and water for injection, and the obtained lyophilized product has good appearance, stable quality, good reconstitution, visible foreign matter and related substances are qualified, suitable for clinical use.
Last Update：2024-01-02 23:10:35
23541-50-6 - Determination of Daunorubicin Hydrochloride in liposomes by HPLC
from VIP Journal Professional Edition
Author:
Zhang Hua , qi Xianrong , Zhang Qiang
Abstract:
Objective: to determine the content of Daunorubicin Hydrochloride in liposomes. Method: using C_(18) column as analytical column, acetonitrile -0.02 mol · L ~(-1) sodium dihydrogen phosphate solution-triethylamine (34:66:0.3, adjusted to pH 4.0 with phosphoric acid) the flow rate was 1.0 mL · min ~(-1), and the detection wavelength was 233nm. The sample volume was 50 μL. Results: in the range of 2.51~25.10 μg · mL ~(-1), the peak area (A) and concentration (C) of Daunorubicin Hydrochloride there is a good linear relationship (r = 0.9993). The detection limit was 40ng · mL ~(-1). The average recoveries of low, medium and high concentrations were 100.8%,103.4% and 102.2%(n = 5) with RSD of 0.49%,0.42% and 1.9%, respectively. Intra-day, inter-day RSD(n = 5) were 1.1%-1.6% and 0.60%-1.5%, respectively. Conclusion: The method is rapid, simple and specific for the determination of Daunorubicin Hydrochloride in liposomes.Key words:
Daunorubicin Hydrochloride liposomes HPLC
DOI:
CNKI:SUN:YWFX.0.2002-04-008
cited:
year:
2002
Last Update：2023-08-16 22:05:47
23541-50-6 - Electrochemical Behavior of Daunorubicin Hydrochloride at Silver disk electrode and its interaction with BSA
from VIP Journal Professional Edition
Author:
Hongfen , Zhang Yong , Liu Jie , Liu Yanmei
Abstract:
The Electrochemical Behavior of Daunorubicin Hydrochloride and its interaction with bovine serum albumin (BSA) were studied by linear sweep voltammetry and cyclic voltammetry. The results showed that Daunorubicin Hydrochloride had a sensitive reduction peak with a peak potential of Britton-Robinson in Ep-0.64V buffer solution at PH 6.50 (. The reduction peak current of Daunorubicin Hydrochloride decreased after the buffer solution was added to BSA. Based on this, an electrochemical method for the determination of BSA was established. Under the optimized conditions, the peak current was linear with the concentration of BSA in the range of 1.0 × 10-8~1.0 × 10-4mol · L-1(r = 0.9965), and the detection limit was 5.0 × 10-9mol · L-1. The binding ratio and binding constant of Daunorubicin Hydrochloride to BSA were also determined.
Key words:
Daunorubicin Hydrochloride silver disk electrode electrochemical behavior bovine serum albumin (BSA
)DOI:
CNKI:SUN:DHXX.0.2009-03-020
cited:
year:
2009
Last Update：2023-08-16 22:05:47
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CAS: 23541-50-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
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Wechat: 0086 189 4982 3763
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Product Name: Daunorubicin HCl Visit Supplier Webpage Request for quotationCAS: 23541-50-6
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