Molecular Formula | C23H45NO4 |
Molar Mass | 399.61 |
BRN | 4152034 |
Storage Condition | 2-8°C |
In vitro study | L-Palmitoylcarnitine (1 µM) inhibits K ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC 50 fell from 62 to 30 µM). Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the K ATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2. |
biological activity | L-Palmitoylcarnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcolemmal membrane and disturbs the membrane lipid environment during ischemia. L-Palmitoylcarnitine inhibited KATP channel activity by interaction with Kir6.2 without affecting single channel conductance. |