2437547-04-9
CCR6 inhibitor 1
CAS: 2437547-04-9
Molecular Formula: C24H23F3N4O3S
2437547-04-9 - Names and Identifiers
| Name | CCR6 inhibitor 1 |
| Synonyms | CCR6 inhibitor 1 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]- |
| CAS | 2437547-04-9 |
2437547-04-9 - Physico-chemical Properties
| Molecular Formula | C24H23F3N4O3S |
| Molar Mass | 504.52 |
| Density | 1.391±0.06 g/cm3(Predicted) |
| Boling Point | 705.4±60.0 °C(Predicted) |
| pKa | 14.71±0.50(Predicted) |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration. |
2437547-04-9 - Reference Information
| biological activity | CCR6 inhibitor 1 is an effective and selective CCR6 inhibitor, with IC50 values of 0.45 and 6 nM for monkey and human CCR6 respectively, and its selectivity is much higher than that of human CCR1 (IC50,> 30000 nM) and CCR7 (IC50,9400 nM). CCR6 inhibitor 1 significantly inhibited ERK phosphorylation. It can be used in the research of autoimmune diseases and cancer. |
| target | moneky CCR6 0.45 nM (IC 50) human CCR6 6 nM (IC 50) human CCR7 9400 nM (IC 50 ) |
| in vitro study | CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration. |
Last Update：2024-04-09 02:00:03
