2438-72-4

Name	bufexamac
Synonyms	cp1044 cp1044j3 bufexamac bufexamicacid 4-butoxyphenylacetohydroxamicacid 4-butoxy-n-hydroxybenzeneacetamide 4-butoxy-n-hydroxy-benzeneacetamid acidep-butoxyphenylacethydroxamique 2-(4-butoxyphenyl)-N-hydroxyacetamide 2-(p-butoxyphenyl)-acetohydroxamicaci 2-(4-butoxyphenyl)acetohydroxamic acid
CAS	2438-72-4
EINECS	219-451-1
InChI	InChI=1/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)

Molecular Formula	C12H17NO3
Molar Mass	223.27
Density	1.1223 (rough estimate)
Melting Point	153-155°
Boling Point	364.56°C (rough estimate)
Solubility	Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethyl acetate and in methanol.
Appearance	neat
Color	White to Off-White
Merck	14,1474
pKa	9.24±0.20(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.5300 (estimate)
In vitro study	Bufexamac is a specific inhibitor of histone type IIB (HDAC6 and HDAC10) deacetylase. Bufexamac inhibits IFN-α secretion in peripheral blood mononuclear cells. Bufexamac is a commonly used contact-related activator and is a non-steroidal anti-inflammatory drug.

WGK Germany	2
RTECS	AK8280000
Toxicity	LD50 orally in mice, rats: >8, >4 g/kg (Lambelin)

Last Update：2024-01-02 23:10:35

introduction	butadiene acid (bufexamac) is a non-steroidal anti-inflammatory drug, crystalline or crystalline powder, slightly smelly, easily soluble in dimethylformamide, slightly soluble in methanol or ethanol, insoluble in water or ether.
pharmacological action	butadiene acid is a non-steroidal anti-inflammatory analgesic, and its anti-inflammatory and analgesic effects are similar to those of phenylbutazone, without glucocorticoid adverse reactions. It can be used for rheumatoid arthritis and hip arthritis. Dermatology topical treatment of eczema, allergic dermatitis, neurodermatitis, solar dermatitis, pruritus, psoriasis, etc.
use	anti-inflammatory drugs synthesized with butyloxy acid are widely used in the treatment of rheumatoid arthritis, eczema and many other skin inflammations, and are equivalent to many corticosteroid preparations (such as fluocinolone cream, betamethasone cream, etc.).
biological activity	Bufexamac is a COX inhibitor, the target is IFN-α, EC50 is 8.9 μM.
Target	Value
IFN-α	8.9 μM
category	toxic substances
toxicity classification	poisoning
acute toxicity	oral-rat LD50: 3370 mg/kg; Oral-mouse LD50: 8000 mg/kg
stimulation data	skin-rabbit 750 mg/30 days mild
flammability hazard characteristics	thermal decomposition discharges toxic nitrogen oxide smoke
storage and transportation characteristics	warehouse ventilation and low temperature drying
fire extinguishing agent	water, dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent

Last Update：2024-04-09 21:04:16

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CAS: 2438-72-4
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