243984-11-4
RESATORVID
CAS: 243984-11-4
Molecular Formula: C15H17ClFNO4S
243984-11-4 - Names and Identifiers
243984-11-4 - Physico-chemical Properties
| Molecular Formula | C15H17ClFNO4S |
| Molar Mass | 361.82 |
| Density | 1.39 |
| Melting Point | 68-69℃ |
| Boling Point | 462.0±55.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 7.08±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | TAK-242 inhibits the TLR4 signaling pathway by directly binding to the Cys747 residue in the intracellular domain of TLR4. TAK-242 can disrupt the interaction of TLR4 with its adaptor molecules TIRAP and TRAM. |
| In vivo study | In mice, a dose of 3 mg/kg TAK242 was effective against acute cerebral ischemia/reperfusion injury. In mouse epithelial tissue, UV-induced AP-1 activation was blocked by topical administration. In a UV-induced skin cancer model, local application of resatorvid can effectively exert its anti-photochemical effect, significantly inhibit the tumor area and its diversity. In the tumor tissues isolated from the administered mice, the activity of the UV-related signaling pathway was decreased, while the activity of the apoptotic signaling pathway was increased (relative to the control group). In mice, TAK-242 significantly reduced neuronal damage after cerebral ischemia. |
243984-11-4 - Reference
| Reference Show more | 1. [IF=2.055] Jieru Han et al."Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study."J Nat Med-Tokyo. 2021 Jan;75(1):37-47 2. [IF=3.337] Yunxiang Cao et al.Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.J Pharmacol Sci. 2021 Nov;: |
243984-11-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.764 ml | 13.819 ml | 27.638 ml |
| 5 mM | 0.553 ml | 2.764 ml | 5.528 ml |
| 10 mM | 0.276 ml | 1.382 ml | 2.764 ml |
| 5 mM | 0.055 ml | 0.276 ml | 0.553 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: TAK-242 Visit Supplier Webpage Request for quotationCAS: 243984-11-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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