2440-60-0
O-Methylisourea
CAS: 2440-60-0
Molecular Formula: C2H6N2O
2440-60-0 - Names and Identifiers
| Name | O-Methylisourea |
| Synonyms | O-Methylisourea o-methylisourea O-Methylisouronium o-Methylisouronium ORTHO-METHYLISOUREA 24285-39-0 (Sulfate) 29427-58-5 (Monosulfate) 5329-33-9 (Hydrochloride) Carbamimidic acid methyl ester Carbamimidic acid, methyl ester methyl imidocarbamate hydrochloride |
| CAS | 2440-60-0 |
| InChI | InChI=1/C2H6N2O.ClH/c1-5-2(3)4;/h1H3,(H3,3,4);1H |
2440-60-0 - Physico-chemical Properties
| Molecular Formula | C2H6N2O |
| Molar Mass | 74.08184 |
| Density | 1.17±0.1 g/cm3(Predicted) |
| Melting Point | 44-45 °C |
| Boling Point | 66.9±23.0 °C(Predicted) |
| Flash Point | 28.4°C |
| Vapor Presure | 148mmHg at 25°C |
| pKa | pK1:9.72(＋1) (25°C) |
| Physical and Chemical Properties | O-methylisourea is a colorless crystal, m. P. 44~45 ℃, can with ethanol and ether vapor evaporation, can absorb moisture and carbon dioxide from the air. |
2440-60-0 - Reference Information
| Use | O-methylisourea is used to synthesize the intermediate 2-methoxy-4-methyl-6-hydroxypyrimidine of the organophosphorus insecticide pyrimidophane. It is an intermediate of pyrimidophane and the insecticide pyrimidine. It is used in medicine to produce the anti-tumor drug fluorouracil. Used as an intermediate in organic synthesis. The pharmaceutical industry is used to produce fluorouracil (antineoplastic drug). |
| production method | is obtained by the reaction of urea and dimethyl sulfate. Put dimethyl sulfate into a dry reaction pot, stir and heat to 40 ℃, then put into dry urea, the temperature naturally rises to about 60 ℃, and the heat preservation reaction lasts for 3 hours to obtain the finished product. There are two methods for the synthesis of O-methylisourea. (1) dimethyl sulfate method (2) cyanamide method is generally used in the industry. 250kg of dimethyl sulfate is put into a 500L reaction kettle, stirred and heated to 80 ℃, then 120kg of urea is added in batches and a small amount. The reaction is exothermic, and the feeding speed is carefully controlled so that the reaction temperature does not exceed 100 ℃. After adding, the reaction temperature is kept at 90 ℃ for 1 hour, cooled to 50-60 ℃, and the material is discharging to obtain about 370kg of colorless viscous liquid, namely O-methyl isourea hydrogen sulfate. |
Last Update：2024-04-09 21:04:16
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