244221-04-3
1-fluoro-4-(2-isocyanoethyl)benzene
CAS: 244221-04-3
Molecular Formula: C9H8FN
244221-04-3 - Names and Identifiers
| Name | 1-fluoro-4-(2-isocyanoethyl)benzene |
| Synonyms | 2-(4-Fluorophenyl)ethyl isocyanide 1-fluoro-4-(2-isocyanoethyl)benzene 1-Fluoro-4-(2-isocyanoethyl)benzene Benzene, 1-fluoro-4-(2-isocyanoethyl)- Benzene, 1-fluoro-4-(2-isocyanoethyl)- (9CI) |
| CAS | 244221-04-3 |
| InChI | InChI=1/C9H8FN/c1-11-7-6-8-2-4-9(10)5-3-8/h2-5H,6-7H2 |
244221-04-3 - Physico-chemical Properties
| Molecular Formula | C9H8FN |
| Molar Mass | 149.1649232 |
244221-04-3 - Introduction
1-fluoro-4-(2-isocyanoethyl)benzene is an organic compound with the chemical formula C9H7FN. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in organic solvents such as ethanol, dichloromethane and ethers
-Melting point:-35 ° C
-Boiling point: 215 ° C
-Density: 1.08g/cm³
Use:
- 1-fluoro-4-(2-isocyanoethyl)benzene can be used as an intermediate in organic synthesis and participate in the synthesis of other compounds.
-In the field of drug synthesis, it can be applied to the preparation of anti-tumor and anti-viral drugs.
Method:
- 1-fluoro-4-(2-isocyanoethyl)benzene generally reacts with 4-fluorophenylacetyl chloride in the presence of potassium carbonate by reacting the raw material benzyl alcohol to obtain the intermediate 4-(4-fluorophenyl) ethanol.
-Then, 4-(4-fluorophenyl) ethanol is oxidized with sodium hypochlorite to obtain the corresponding aldehyde.
-Finally, the aldehyde is reacted with thiourea to produce 1-fluoro-4-(2-isocyanoethyl)benzene.
Safety Information:
- 1-fluoro-4-(2-isocyanoethyl)benzene is irritating, and contact with skin and eyes may cause irritation and inflammation.
-Wear suitable personal protective equipment during operation, including chemical goggles, protective gloves and protective clothing.
-In the event of accidental inhalation or ingestion, seek immediate medical attention and provide information about the compound to your doctor.
Please note that when conducting any chemical experiments or using chemicals, it is important to take appropriate safety measures and ensure that the nature and characteristics of the compound are understood before operation.
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in organic solvents such as ethanol, dichloromethane and ethers
-Melting point:-35 ° C
-Boiling point: 215 ° C
-Density: 1.08g/cm³
Use:
- 1-fluoro-4-(2-isocyanoethyl)benzene can be used as an intermediate in organic synthesis and participate in the synthesis of other compounds.
-In the field of drug synthesis, it can be applied to the preparation of anti-tumor and anti-viral drugs.
Method:
- 1-fluoro-4-(2-isocyanoethyl)benzene generally reacts with 4-fluorophenylacetyl chloride in the presence of potassium carbonate by reacting the raw material benzyl alcohol to obtain the intermediate 4-(4-fluorophenyl) ethanol.
-Then, 4-(4-fluorophenyl) ethanol is oxidized with sodium hypochlorite to obtain the corresponding aldehyde.
-Finally, the aldehyde is reacted with thiourea to produce 1-fluoro-4-(2-isocyanoethyl)benzene.
Safety Information:
- 1-fluoro-4-(2-isocyanoethyl)benzene is irritating, and contact with skin and eyes may cause irritation and inflammation.
-Wear suitable personal protective equipment during operation, including chemical goggles, protective gloves and protective clothing.
-In the event of accidental inhalation or ingestion, seek immediate medical attention and provide information about the compound to your doctor.
Please note that when conducting any chemical experiments or using chemicals, it is important to take appropriate safety measures and ensure that the nature and characteristics of the compound are understood before operation.
Last Update：2024-04-09 21:00:56
