252720-32-4
4-(Boc-amino)-1-Cbz-piperidine-4-carboxylic acid
CAS: 252720-32-4
Molecular Formula: C19H26N2O6
252720-32-4 - Names and Identifiers
252720-32-4 - Physico-chemical Properties
| Molecular Formula | C19H26N2O6 |
| Molar Mass | 378.42 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Boling Point | 556.5±50.0 °C(Predicted) |
| Flash Point | 290.337°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 3.86±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.567 |
252720-32-4 - Risk and Safety
| HS Code | 29333990 |
252720-32-4 - Introduction
4-(Boc-amino)-acid is an organic compound also known as 4-(Boc-amino)-1-cbz-piperidine-1-carboxylic acid 4-methyl ester. Its chemical structure contains a 4-aminopiperidine ring and a Boc protecting group.
Nature:
4-(Boc-amino)-acid is a solid, usually white crystal. Its molecular formula is C17H23N3O5, the relative molecular mass is 361.38. It has good solubility at room temperature and is soluble in some organic solvents such as methanol and dimethylformamide.
Use:
4-(Boc-amino)-acid is a commonly used organic synthesis intermediate. It can be used to synthesize biologically active compounds, such as drug molecules and protein small molecule mimetics. It can also be used as a starting material for the synthesis of collagen and polypeptides.
Method:
4-(Boc-amino)-The preparation of acid can be carried out by the following steps:
1. First, 4-amino piperidine and 1,1-dichlorocyclopentane are condensed to generate 4-(piperidin-4-yl) piperidine.
2. The 4-(piperidin-4-yl) piperidine is then reacted with P-Aminobenzoic anhydride to form 4-(n-benzyl-2-oxodibenzoyl)-piperidine.
3. Finally, 4-(n-benzyl-2-oxodibenzoyl)-piperidine is reacted with P-methylaminobenzoic acid tert-butyl ester to give 4-(Boc-amino)-acid.
Safety Information:
regular chemical handling precautions and safety laboratory regulations should be observed when handling 4-(Boc-amino)-acid. It may cause irritation to the eyes, skin and respiratory tract, please avoid contact. When using, please wear appropriate protective equipment, such as gloves, safety glasses and protective masks. It is best to use in a well-ventilated area and avoid inhaling dust or spray of solution. If exposed or inhaled, rinse immediately with plenty of water and seek medical help.
Nature:
4-(Boc-amino)-acid is a solid, usually white crystal. Its molecular formula is C17H23N3O5, the relative molecular mass is 361.38. It has good solubility at room temperature and is soluble in some organic solvents such as methanol and dimethylformamide.
Use:
4-(Boc-amino)-acid is a commonly used organic synthesis intermediate. It can be used to synthesize biologically active compounds, such as drug molecules and protein small molecule mimetics. It can also be used as a starting material for the synthesis of collagen and polypeptides.
Method:
4-(Boc-amino)-The preparation of acid can be carried out by the following steps:
1. First, 4-amino piperidine and 1,1-dichlorocyclopentane are condensed to generate 4-(piperidin-4-yl) piperidine.
2. The 4-(piperidin-4-yl) piperidine is then reacted with P-Aminobenzoic anhydride to form 4-(n-benzyl-2-oxodibenzoyl)-piperidine.
3. Finally, 4-(n-benzyl-2-oxodibenzoyl)-piperidine is reacted with P-methylaminobenzoic acid tert-butyl ester to give 4-(Boc-amino)-acid.
Safety Information:
regular chemical handling precautions and safety laboratory regulations should be observed when handling 4-(Boc-amino)-acid. It may cause irritation to the eyes, skin and respiratory tract, please avoid contact. When using, please wear appropriate protective equipment, such as gloves, safety glasses and protective masks. It is best to use in a well-ventilated area and avoid inhaling dust or spray of solution. If exposed or inhaled, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:32:39
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