25561-30-2
bis(trimethylsilyl)trifluoroacetamide
CAS: 25561-30-2
Molecular Formula: C8H18F3NOSi2
25561-30-2 - Names and Identifiers
25561-30-2 - Physico-chemical Properties
| Molecular Formula | C8H18F3NOSi2 |
| Molar Mass | 257.4 |
| Density | 0.97g/mL(lit.) |
| Melting Point | -10°C |
| Boling Point | 45-50°C14mm Hg(lit.) |
| Flash Point | 75°C |
| Water Solubility | hydrolyses |
| Solubility | Miscible with chloroform. |
| Vapor Presure | 0.193mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 0.971 |
| Color | Colorless to pale yellow |
| BRN | 3607620 |
| pKa | 1.82±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.384(lit.) |
| Physical and Chemical Properties | Appearance: colorless transparent liquid |
| Use | Pharmaceutical Intermediates |
25561-30-2 - Risk and Safety
| Risk Codes | R11 - Highly Flammable R34 - Causes burns R10 - Flammable R35 - Causes severe burns R14 - Reacts violently with water |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. |
| UN IDs | UN 2924 3/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | Yes |
| HS Code | 29310095 |
| Hazard Note | Flammable/Moisture Sensitive |
| Hazard Class | 3 |
| Packing Group | III |
25561-30-2 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | N,O-bis-trimethylsilyl trifluoroacetamide is an important pharmaceutical intermediate, which can reduce the polarity of hydroxyl compounds and increase their volatility, making the sample more suitable for GC analysis. It is mainly used as a neutral silane reagent in the silane protection of amino acids, phenols, carboxylic acids and enols. As a mild neutral silane reagent, it not only has high reactivity and good selectivity, but also has the advantages of high reaction yield and simple post-treatment. Pharmaceutical intermediates. 99% high purity grade is used in GC-MS system analysis of furfural content in food. Silanization reagents and derivatization reagents for gas chromatography |
| preparation | a processing technology of N,O-bis-trimethylsilyl trifluoroacetamide: N,O-bis-trimethylsilyl trifluoroacetamide, whose molecular formula is CF3CON[(CH3)3Si]2 is a kind of silicylation reagent, which is composed of raw materials trimethylchlorosilane, triethylamine and trifluoroacetamide, it is characterized in that the molar ratios of the raw materials trimethylchlorosilane, triethylamine and trifluoroacetamide are respectively 1.2-4:2-4:1. The synthesized N,O-bis-trimethylsilyl trifluoroacetamide is processed by adding triethylamine and trifluoroacetamide to the reaction kettle during synthesis, stirring for 1 hour, then dropping trimethylchlorosilane to the reaction kettle under the protection of N2 gas, controlling the temperature to be within the range of <50 ℃, filling within 2-6 hours, then protecting the reaction for 8-16 hours at 40-65 ℃, and cooling to below 35 ℃ after the reaction is over, discharge. The reacted materials are added to a closed centrifuge for solid-liquid separation, and the mother liquor is sent to a concentrated kettle for concentration. The concentration temperature is controlled between 60-100 ℃ and the pressure is -0.2 to -08 atmospheric pressure. The concentrated mother liquor is then sent to a rectification kettle for rectification. The rectification conditions are as follows: the temperature is controlled at 60-100 ℃, the pressure is -0.2 to -0.998 atmosphere, the tower height is 6-15 meters, the colorless and transparent liquid after rectification is packed under the protection of N2 gas to obtain the finished product. |
Last Update：2024-04-10 22:29:15
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