Overview | coriaria lactone (CL) is a kind of sesquiterpene lactone contained in the genus of Mulberry and its parasitism, belonging to a class of compounds in the class of the bitter toxin sesquiterpenes. Up to now, many kinds of coriaria lactones such as coriaria toxin, hydroxy-coriaria toxin and massanning have been isolated from plants. The shade of horse mulberry leaves and acetone were studied and filtered, the filtrate was concentrated and extracted with chloroform, the extract was extracted with ethyl acetate, and then by Gel chromatography, the separation of A significant anticancer activity of coriaria toxin A. |
effect | coriaria lactone has significant pharmacological effects on the central nervous system and can be used for the treatment of schizophrenia, in particular, the curative effect of hydroxy Mulberry toxin is the best. Coriaria lactone is also commonly used in domestic chemical epileptogenic agents and biological pesticides. Horse Mulberry parasitism is parasitic on the tree of horse Mulberry can be a plant of the genus Mulberry parasitism or hairy leaf Mulberry parasitism (Persimmon parasitism), the Philippines, Sichuan Mulberry parasitism, large poison, with wind and dampness, phlegm, the effect of promoting blood circulation and relieving pain is used for rheumatism, waist and knee pain, schizophrenia, migraine, traumatic injury, etc. |
activity Study | coriaria lactone, which is the main active component in the fruit, the dissolved portion of the toxin is quickly absorbed from the small intestine to the liver and circulates to the whole body after miseating Mulberry. After absorption, a small part of the toxin is excreted by the kidneys, and most of the toxins are destroyed in the body. Coriaria lactone can cause liver injury, kidney injury, myocardial injury, apoptosis, and cytotoxicity. The pathological changes are mainly brain and lung edema, nervous system degeneration, necrosis, severe liver degeneration, myocardial interstitial congestion, edema and myocardial fiber breakage, leading to respiratory and circulatory failure. |
category | toxic substances |
toxicity grade | highly toxic |
Acute toxicity | intravenous-rat LDL0: 0.7 mg/kg; Intravenous-mouse LDL0: 1.0 mg/kg |
flammability hazard characteristics | flammable, spicy and irritating smoke |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from acids and food |
fire extinguishing agent | water, sand |