257876-05-4
5-Methyl-2-pyridylzinc bromide
CAS: 257876-05-4
Molecular Formula: C6H6BrNZn
257876-05-4 - Names and Identifiers
257876-05-4 - Physico-chemical Properties
| Molecular Formula | C6H6BrNZn |
| Molar Mass | 237.41 |
| Density | 0.959g/mLat 25°C |
| Flash Point | 1°F |
| Exposure Limit | ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)OSHA: TWA 200 ppm(590 mg/m3)NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) |
| Storage Condition | 2-8°C |
257876-05-4 - Risk and Safety
| Risk Codes | R14 - Reacts violently with water R19 - May form explosive peroxides R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R41 - Risk of serious damage to eyes R40 - Limited evidence of a carcinogenic effect R37 - Irritating to the respiratory system R11 - Highly Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 3399 4.3/PG 2 |
| WGK Germany | 1 |
257876-05-4 - Introduction
5-Methyl-2-pyridylzinc bromide(5-Methyl-2-pyridylzinc bromide) is an organic zinc compound. Its chemical formula is C6H6BrNZn, the appearance is colorless or yellowish solid. The following is an introduction to its nature, use, formulation and safety information:
Nature:
1. Appearance: colorless or yellowish solid;
2. melting point: about 150 ℃;
3. solubility: soluble in ether, dichloromethane and other organic solvents, insoluble in water.
Use:
5-Methyl-2-pyridylzinc bromide is an important organic synthesis reagent, often used in organic synthesis reactions, especially as a ligand or reagent involved in the formation of C- C or C- X bonds. It is widely used in transition metal-catalyzed reactions, cross-coupling reactions, palladium-catalyzed carbonylation of carboxylic acids, etc.
Preparation Method:
The preparation of 5-Methyl-2-pyridylzinc bromide can be carried out by the following steps:
1.5-methyl -2-pyridine sodium bromide and zinc chloride react in ether to generate 5-Methyl-2-pyridylzinc bromide.
Safety Information:
When using and storing 5-Methyl-2-pyridylzinc bromide, you need to pay attention to the following safety precautions:
1. Although there is no detailed toxicity data, as an organometallic compound, it may cause irritation and danger to the human body. During the operation, it is necessary to follow good laboratory safety practices;
2. avoid contact with skin, eyes and respiratory tract;
3. Operate in a well-ventilated place and avoid inhaling its vapor;
4. avoid contact with strong oxidants, acids and water to avoid dangerous reactions;
5. Store in a dry, cool place, away from fire and combustibles.
Nature:
1. Appearance: colorless or yellowish solid;
2. melting point: about 150 ℃;
3. solubility: soluble in ether, dichloromethane and other organic solvents, insoluble in water.
Use:
5-Methyl-2-pyridylzinc bromide is an important organic synthesis reagent, often used in organic synthesis reactions, especially as a ligand or reagent involved in the formation of C- C or C- X bonds. It is widely used in transition metal-catalyzed reactions, cross-coupling reactions, palladium-catalyzed carbonylation of carboxylic acids, etc.
Preparation Method:
The preparation of 5-Methyl-2-pyridylzinc bromide can be carried out by the following steps:
1.5-methyl -2-pyridine sodium bromide and zinc chloride react in ether to generate 5-Methyl-2-pyridylzinc bromide.
Safety Information:
When using and storing 5-Methyl-2-pyridylzinc bromide, you need to pay attention to the following safety precautions:
1. Although there is no detailed toxicity data, as an organometallic compound, it may cause irritation and danger to the human body. During the operation, it is necessary to follow good laboratory safety practices;
2. avoid contact with skin, eyes and respiratory tract;
3. Operate in a well-ventilated place and avoid inhaling its vapor;
4. avoid contact with strong oxidants, acids and water to avoid dangerous reactions;
5. Store in a dry, cool place, away from fire and combustibles.
Last Update：2024-04-10 22:29:15
