25849-90-5
2-8-Angiotensin II, 2-glycine-5-L-isoleucine-
CAS: 25849-90-5
Molecular Formula: C42H57N9O9
25849-90-5 - Names and Identifiers
| Name | 2-8-Angiotensin II, 2-glycine-5-L-isoleucine- |
| Synonyms | TRV055 2-8-Angiotensin II, 2-glycine-5-L-isoleucine- |
| CAS | 25849-90-5 |
25849-90-5 - Physico-chemical Properties
| Molecular Formula | C42H57N9O9 |
| Molar Mass | 831.97 |
| In vitro study | TRV055 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling. |
25849-90-5 - Reference Information
| Biological activity | TRV055 is a Gq-biased ligand of type 1 angiotensin II receptor (AT1R). TRV055 effectively stimulates cell Gq-mediated signaling. TRV055 can be used to develop Gq-biased AT1R agonists. |
| in vitro study | TRV055 is a "gain-of-function" ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), "Gq-biased" AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling. |
Last Update：2024-04-09 20:52:54
