2628-17-3
4-Vinylphenol
CAS: 2628-17-3
Molecular Formula: C8H8O
2628-17-3 - Names and Identifiers
| Name | 4-Vinylphenol |
| Synonyms | 4-Vinylphenol p-Vinylphenol 4-Hydroxystyrene PARA-VINYLPHENOL 4-Hydrozystyrene 4-Vinylphenol(4-Hydroxystyrene) 4-vinylphenol,4-ethenyl-phenol,p-hydroxystyrene |
| CAS | 2628-17-3 |
| EINECS | 220-103-6 |
| InChI | InChI=1/C8H8O/c1-2-7-3-5-8(9)6-4-7/h2-6,9H,1H2 |
2628-17-3 - Physico-chemical Properties
| Molecular Formula | C8H8O |
| Molar Mass | 120.15 |
| Density | 1.04 |
| Melting Point | 73 °C |
| Boling Point | 228.85°C (estimate) |
| Flash Point | >230°F |
| JECFA Number | 711 |
| Water Solubility | Slightly miscible with water. |
| Solubility | Chloroform (Sparingly), DMSO (Slightly) |
| Vapor Presure | 9.38hPa at 25℃ |
| Appearance | Liquid |
| Color | Clear colorless to orange |
| BRN | 506844 |
| pKa | 9.95±0.26(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Light Sensitive |
| Sensitive | Hygroscopic |
| Refractive Index | 1.4440 |
| MDL | MFCD00017593 |
| In vitro study | 4-Vinylphenol (12.5-200 µg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 µg/mL. 4-Vinylphenol (0.15 or 0.3 µg/mL; 3 days) reduces sphere‑formation and vimentin expression on CSCs in breast cancer. 4-Vinylphenol (50, 100 µg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol (100 µg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis. |
2628-17-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 2 |
| RTECS | SN3800000 |
| HS Code | 29089990 |
2628-17-3 - Reference Information
| FEMA | 3739 | P-VINYLPHENOL |
| LogP | 2.3 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | GRAS(FEMA). |
| usage limit | FEMA(mg/kg): baked products, meat products, sauces, 5.0; Cold drinks, sweet sauce, 2.5; Gel, pudding, dessert, icing, nut products, hard candy, 2.0; Alcohol-free beverage 1.5; Alcohol-containing beverage 0.5; Milk substitute 3.0; Gum sugar 10.0. |
| Biological activity | 4-Vinylphenol exists in medicinal grass, Hedyotis diffusa, wild rice, and is also the lactic acid bacteria in wine to p-coumaric acid and ferulic acid Metabolites. 4-Vinylphenol induces apoptosis (apoptosis), inhibits angiogenesis and inhibits invasive breast tumor growth in vivo. |
Last Update：2024-04-09 02:00:07
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