263717-53-9
PPT
CAS: 263717-53-9
Molecular Formula: C24H22N2O3
263717-53-9 - Names and Identifiers
| Name | PPT |
| Synonyms | PPT |
| CAS | 263717-53-9 |
263717-53-9 - Physico-chemical Properties
| Molecular Formula | C24H22N2O3 |
| Molar Mass | 386.44 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | Propyl pyrazole triol is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). |
| Target | ERα |
263717-53-9 - Reference
| Reference Show more | 1: Alda JO, Valero MS, Pereboom D, Gros P, Garay RP. Endothelium-independent vasorelaxation by the selective alpha estrogen receptor agonist propyl pyrazole triol in rat aortic smooth muscle. J Pharm Pharmacol. 2009 May;61(5):641-6. doi: 10.1211/jpp/61.05.0013. PubMed PMID: 19406003. 2: Vijaykumar D, Al-Qahtani MH, Welch MJ, Katzenellenbogen JA. Synthesis and biological evaluation of a fluorine-18 labeled estrogen receptor-alpha selective ligand: [18F] propyl pyrazole triol. Nucl Med Biol. 2003 May;30(4):397-404. PubMed PMID: 12767397. 3: Lundholm L, Bryzgalova G, Gao H, Portwood N, Fält S, Berndt KD, Dicker A, Galuska D, Zierath JR, Gustafsson JA, Efendic S, Dahlman-Wright K, Khan A. The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms. J Endocrinol. 2008 Nov;199(2):275-86. doi: 10.1677/JOE-08-0192. Epub 2008 Aug 29. PubMed PMID: 18757549. 4: Massart R, Barnea R, Dikshtein Y, Suderman M, Meir O, Hallett M, Kennedy P, Nestler EJ, Szyf M, Yadid G. Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving. J Neurosci. 2015 May 27;35(21):8042-58. doi: 10.1523/JNEUROSCI.3053-14.2015. PubMed PMID: 26019323. |
263717-53-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.588 ml | 12.939 ml | 25.877 ml |
| 5 mM | 0.518 ml | 2.588 ml | 5.175 ml |
| 10 mM | 0.259 ml | 1.294 ml | 2.588 ml |
| 5 mM | 0.052 ml | 0.259 ml | 0.518 ml |
Last Update：2024-01-02 23:10:35
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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