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2646-71-1

Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt

CAS: 2646-71-1

Molecular Formula: C21H31N7NaO17P3

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2646-71-1 - Names and Identifiers

Name Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt
Synonyms BETA-NADPH
Beta-Nadph Tetrasodium Salt
TRIPHOSPHOPYRIDINE NUCLEOTIDE, REDUCED FORM, TETRASODIUM
BETA-TRIPHOSPHOPYRIDINE NUCLEOTIDE, SODIUM, REDUCED FORM
TRIPHOSPYRIDINE NUCLEOTIDE, REDUCED FORM TETRASODIUM SALT
TRIPHOSPHOPYRIDINE NUCLEOTIDE, REDUCED FORM TETRASODIUM SALT
dihydronicotinamide-adenine dinucleotide phosphate tetrasodium
BETA-TRIPHOSPHOPYRIDINE NUCLEOTIDE TETRASODIUM SALT,REDUCED FORM
Dihydronicotinamide Adenine Dinucleotide Pphosphate Tetrasodium Salt
Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate
tetrasodium [(2R,3S,4R,5R)-2-(6-aminopurin-9-yl)-5-[[[[(2R,3R,4S,5S)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-4-hydroxy-tetrahydrofuran-3-yl] phosphate
CAS 2646-71-1
EINECS 220-163-3
InChI InChI=1/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11-,13+,14-,15+,16+,20+,21-;;;;/m1..../s1

2646-71-1 - Physico-chemical Properties

Molecular FormulaC21H31N7NaO17P3
Molar Mass769.42
Melting Point>250°C (dec.)
Water SolubilitySoluble in water (50 mg/ml).
Solubility 10 mM NaOH: soluble50mg/mL, clear
AppearanceWhite to yellowish powder
ColorWhite to Off-white
Merck14,6348
Storage ConditionKeep in dark place,Inert atmosphere,Store in freezer, under -20°C
SensitiveLight Sensitive
MDLMFCD00057028
UseThis product is for scientific research only and shall not be used for other purposes.

2646-71-1 - Risk and Safety

Risk CodesR36/37/38 - Irritating to eyes, respiratory system and skin.
R11 - Highly Flammable
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37 - Wear suitable protective clothing and gloves.
WGK Germany3
FLUKA BRAND F CODES3-10-23
HS Code29349990

2646-71-1 - Reference

Reference
Show more
1. Chen Rongda Xie Jing Shi Yu Rui Liu Guiming Zheng Mei Zhu Li Li. Effects of CYP3A4 enzyme on metabolism of flavonoids in Smilax glabra [J]. Analytical Laboratory 2020 39(07):760-765.
2. Zhang Song, Li Xiaoshi, Xiaodan et al. Optimization of culture temperature and rotation speed of gene engineering bacteria producing ketoreductase [J]. China brewing 2016 35(02):85-89.
3. Zhu Lijuan, Yu Tao, Gu Ying, et al. Efficient Preparation of (R)-2-chloro-1-(3-chlorophenyl) ethanol by dual-enzyme system [J]. Journal of Food Science and Biotechnology, 2016, 35(03):278-283.
4. Shi Xiaodan Li Xiao Luo Yu Di et al. Establishment of a method for determination of keto reductase activity in fermentation broth [J]. China brewing 2014 33(009):151-155.
5. Zhu Lijuan, Hu Die, storage of Yaqin, etc. Preparation of chiral compound (S)-styrene oxide by multi-enzyme coupling catalysis [J]. Journal of Food and Biotechnology, 2017, 36(5):473-478.
6. Zhou Guojian, Ye Dongting, Deng Xuxing. Effects of Banlangen granules, Yinzhihuang granules and compound berberine tablets on activity of drug metabolizing enzyme cyp3a_4 [J]. Chinese Medicine Review, 2017,23(03):72-74.
7. Wang Jie, Wang dujun, Li Fengwei, etc. Optimization of conditions for enrichment of γ-aminobutyric acid and flavonoids from Salicornia seed germination and study on key enzyme activities [J]. Food Research and Development, 2019, v.40;No.372(23):66-73.
8. Yu Tao, Hu Die, Min-Chen, et al. Enzymatic properties of recombinant glucose dehydrogenase and its coupled coenzyme regeneration [J]. Journal of Food and Biotechnology, 2014, 033(009):910-916.
9. Wang Wei, Li Guanping, Zhang Yu, et al. Determination of activity of active peptide HMG-CoA reductase inhibitor by HPLC [J]. Zhejiang Journal of Agricultural Sciences 2015 027(004):652-656.
10. Wang, Xiaohong, and Wanzhong Li. "Antioxidantactivity of polyphenolsfrom Toona sinensis roem seeds and the inhibition of aldose reductase." African Journal of Traditional, Complementary and Alternative Medicines 13.1 (2016): 99-104.10.4314/ajtcam.v13i1.14
11. [IF = 2.112] Yu Tao et al."Reduction of m-chlorophenacyl chloride coupled with regeneration of NADPH by recombinant Escherichia coli cells co-expressing both carbonyl reductase and glucose 1-dehydrogenase."Ann Microbiol. 2016 Mar;66(1):343-350
12. [IF=11.413] Yan Yin et al."De novo biosynthesis of liquiritin in Saccharomyces cerevisiae."Acta Pharm Sin B. 2020 Apr;10:711
13. [IF=4.155] Siqi Zhang et al."Step-wise immobilization of multi-enzymes by zirconium-based coordination polymer in situ self-assembly and specific absorption."J Inorg Biochem. 2020 Jul;208:111093
14. [IF=3.5] Yue Li et al."Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles."Toxicol In Vitro. 2022 Apr;80:105324
15. [IF=5.279] Chenggang Song et al."Bioactive Monomer and Polymer Polyketides from Edible Mushroom Cortinarius caerulescens as Glutamate Dehydrogenase Inhibitors and Antioxidants."J Agr Food Chem. 2022;XXXX(XXX):XXX-XXX

2646-71-1 - Nature

Open Data Verified Data
  • white powder, easy to absorb moisture, soluble in water and methanol, slightly soluble in ethanol, almost insoluble in ether and ethyl acetate.
  • coenzyme II and coenzyme I differ only by one phosphate group, I .e., coenzyme I is nicotinamide adenine dinucleotide (NAD) or pyridine diphosphate nucleotide (DPN); coenzyme II is nicotinamide adenine dinucleotide phosphate (NADP) or pyridine nucleotide triphosphate (TPN). NADP is produced by phosphorylation of NAD by kinases, and NADP is an indispensable hydrogen transporter in biological oxidation. Therefore, this product can strengthen the oxidation of substances in the body and supply energy.
Last Update：2024-01-02 23:10:35

2646-71-1 - Introduction

Usually used as an electron donor, it is a cofactor of many oxidoreductase (including nitric oxide synthase).
Last Update：2022-10-16 17:24:08

2646-71-1 - Use

Open Data Verified Data

This product is not only used as a diagnostic reagent for enzyme activity, but also can be used as a component of coenzyme complex.

Last Update：2022-01-01 11:12:58

2646-71-1 - Reference Information

Introduction NADPH is reduced coenzyme, scientific name: reduced nicotinamide adenine dinucleotide phosphate (triphosphopyridine
nucleotide), is nicotinamide adenine dinucleotide (NAD) The phosphorylated derivative at the 2 '-position of the ribose ring system connected to adenine in the chemical reactions in many organisms, which acts as a hydrogen transfer body, and participate in the synthesis of a variety of metabolic reactions, such as the synthesis of lipids, fatty acids and nucleotides, and can also provide energy for the fixation of carbon dioxide in dark reactions.
application there are reports in the literature that many life activities such as cell growth, division, differentiation, migration, apoptosis and aging are also closely related to NADPH. Moreover, maintaining the fixed concentration of NADPH(NADH) or adding auxiliary NADPH(NADH) can resist the apoptosis and aging process of cells and delay the aging of the body. The latest research found that NADPH and NADH play important functions under physiological and pathological conditions. At present, the research on the function and metabolism of intracellular NADPH(NADH) has become an international research hotspot.
Biological activity NADPH tetrasodium salt is a cofactor used to provide electrons and hydrogen to certain enzyme-catalyzed reactions.
Use Usually used as an electron donor, it is a coenzyme (cofactor) of many oxidoreductase (including nitric oxide synthase).
Last Update：2024-04-10 22:29:15
2646-71-1
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Wuhan Xingzhongcheng Chemical limited company
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Product Name: Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt Request for quotation
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Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
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Wuhan Boye Science And Technology Development Co., Ltd.
Product Name: NADPH, Tetrasodium Salt Request for quotation
CAS: 2646-71-1
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380 Click to send a QQ message
Wechat: 15387090420
Shanghai Worldyang Chemical Co.,Ltd.
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Email: charles7788@worldyachem.com
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2646-71-1
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