265134-87-0 - Names and Identifiers
Name | (6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy)
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Synonyms | Trafizidine intermediate intermediate of Lurbinectedin (6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy) (6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy)
Corey 16 (6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy)methyl)-5-hydroxy-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-6,6a,7,13,14,16-hexahydro-12H-7,13-epiminobenzo[4,5]azocino[1,2-b][1,3]dioxolo[4,5-h]isoquinoline-14-carbonitrile 7,13-Imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-14-carbonitrile, 16-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,6a,7,13,14,16-hexahydro-5-hydroxy-9-methoxy-8-(methoxymethoxy)-4,10,17-trimethyl-, (6aS,7R,13S,14R,16R)-
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CAS | 265134-87-0
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265134-87-0 - Physico-chemical Properties
Molecular Formula | C34H47N3O7Si
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Molar Mass | 637.84 |
Density | 1.26±0.1 g/cm3(Predicted) |
Boling Point | 693.6±55.0 °C(Predicted) |
pKa | 10.50±0.60(Predicted) |
265134-87-0 - Introduction
Trabetidine (also known as tribetrine) is a pharmaceutical intermediate, which is mainly used in the synthesis of anti-cancer drugs and antiviral drugs. The following is an introduction to the nature, use, formulation and safety information of (6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy):
properties:(6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy) is an organic compound with a Spiro structure in its chemical structure. It is a colorless to pale yellow crystal or solid. It is chemically stable and can be dissolved in organic solvents under certain conditions.
use:(6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy) is an important drug synthesis intermediates. It is widely used in the synthesis of various anti-cancer drugs and antiviral drugs, such as docetaxel (an anti-cancer drug) and ringomycin (an antibiotic). The structure and properties of (6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy) make it have good reactivity and selectivity in drug synthesis.
Preparation Methods:(6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy) can be prepared in a variety of ways. One commonly used method is synthesis by cyclization reactions between Spiro compounds. The specific steps include selecting suitable starting materials, and after several chemical reactions, (6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy) is finally obtained.
Safety Information:(6aS,7R,13S,14R,16R)-16-(((tert-butyldimethylsilyl)oxy) need to pay attention to safety when used in chemical experiments and drug synthesis. It may be irritating to the eyes, skin and respiratory system. Therefore, appropriate personal protective equipment such as goggles, gloves and masks should be worn during operation. In addition, it should be stored in a dry, well-ventilated place, away from fire and oxidizing agents. If ingested or inhaled by mistake, you should seek medical attention in time. When handling (6aS,7R,13S,14R,16R)-16-((tert-butyldimethylsilyl)oxy) waste, relevant safety and environmental protection regulations should be followed.
Last Update:2024-04-09 20:52:54