Molecular Formula | (C10H18N8)m.(C6H16N2)n.xHCl,(m,n |
Molar Mass | 366.52 |
Storage Condition | Room Temprature |
Use | Uses polyhexamethylene biguanide Disinfection, bactericidal, antifungal. This product has a broad-spectrum antibacterial effect on Gram-positive bacteria, gram-negative bacteria, fungi and yeast. Can be widely used in daily chemical industry, water treatment, medical and health fields. Commonly used in women's lotion, sanitary wipes sterilization fungicide, fruit and vegetable, aquatic product disinfectant, sewage treatment flocculation disinfectant and other products. |
Reference Show more | 1. [IF=6.353] Feng Zhaoxuan et al."Design and characterization of plasticized bacterial cellulose/waterborne polyurethane composite with antibacterial function for nasal stenting."Regen Biomater. 2020 Dec;7(6):597-608 |
Abstract:
guanidine-based polymer is one of the bioactive polymers. It is a strong organic base and is used as a basic catalyst or adjuvant in many reactions [1]. As early as 1861, Streeker discovered guanidine (CH5N3), from the structural point of view, guanidine is iminourea, also known as carbamic acid amidine. In nature, guanidine is present in trace amounts in plants such as sugar beet, Rice Husk, mushrooms and legumes, and trace amounts of guanidine are also contained in human and animal bodies, certain diseases can cause increased levels of guanidine in the blood or urine [2].
Key words:
hydrochloride methylene biological activity guanidine-based polymer synthesis biguanide dicyandiamide alkaline catalyst hexamethylene diamine antibacterial agent
cited:
year:
2011
invention patent
Application (patent) number:
CN201810352945.8
application date:
20180419
Public/Announcement Number:
CN108403465A
Public/announcement date:
20180817
applicant (patent):
Shandong shunhao polyurethane insulation Material Co., Ltd.
inventor:
Haiming Zhu , Wang Wei , Han Lixia
National and provincial code:
CN370784
Abstract:
The invention provides a polyhexamethylene guanidine/biguanide hydrochloride hand sanitizer and a preparation method thereof, comprising 6.510.5% surfactant, 0.52.5% polyhexamethylene guanidine/biguanide hydrochloride, 8.512.5% amphoteric surfactants, 1.03.0% Nonionic Surfactant, 1.53.5% glyceryl cocoate, 0.30.7% preservatives, 0.51.1% pearlescent agent, 1.53.5% thickener, 0.81.6% chelating agent, 0.52.5% citric acid, 0.30.9% carboxymethyl cellulose, the rest is deionized water; Polyhexamethylene guanidine/biguanide hydrochloride is added to the solution of the hand sanitizer of the present invention, which can form multiple adsorption points with the skin, the hand sanitizer with polyhexamethylene guanidine/biguanide hydrochloride is more safe because of its lysozyme blocking cells and bactericidal effect without any irritation to the skin and eyes.
Lu Longxi , Zheng Yunyan , calderay , Lin Junming , He
Abstract:
Objective to study the Disinfection related properties of polyhexamethylene biguanide hydrochloride. Methods quantitative germicidal test, broth dilution method and animal test were used to observe the bactericidal effect and toxicity of polyhexamethylene guanidine hydrochloride. Results The MIC of polyhexamethylene biguanide hydrochloride against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa was 2 mg/L ~ 50 mg/L, the MIC for C. Albicans was 100 mg/L. With 200mg/L polyhexamethylene biguanide hydrochloride suspension of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus 20 min, killing the value of> 5.00, the average killing logarithm of Candida albicans exposed for 30 min was more than 4.00. Polyhexamethylene biguanide hydrochloride in mice with acute oral LD50>5 000 mg/kg, mouse bone marrow polychromatic erythrocyte micronucleus test results were negative. Conclusion polyhexamethylene biguanide hydrochloride has good efficacy in killing vegetative forms and fungi of bacteria, and has strong antibacterial effect. It belongs to non-toxic substances and has no mutagenicity.stowed
Key words:
polyhexamethylene biguanide hydrochloride bacteriostatic effect germicidal efficacy biofilm toxicity
DOI:
CNKI:SUN:ZGXD.0.2011-05-004
cited:
year:
2011