Name | Indazole |
Synonyms | Indazole INDAZOLE Isoindazole 2-Azaindole 1H-Indazole BENZOPYRAZOLE Benzopyrazole 1,2-Diazaindene BENZ-1,2-DIAZOLE 1H-Benzopyrazole IFLAB-BB F1918-0009 |
CAS | 271-44-3 |
EINECS | 205-978-4 |
InChI | InChI=1/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) |
Molecular Formula | C7H6N2 |
Molar Mass | 118.14 |
Density | 1.4220 (rough estimate) |
Melting Point | 145-148 °C (lit.) |
Boling Point | 270 °C/743 mmHg (lit.) |
Flash Point | 270°C |
Water Solubility | SOLUBLE IN HOT WATER |
Vapor Presure | 0.0116mmHg at 25°C |
Appearance | White crystal |
Color | White to beige |
Merck | 14,4936 |
BRN | 109676 |
pKa | 14.00±0.10(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.5500 (estimate) |
MDL | MFCD00005691 |
Physical and Chemical Properties | White needle-like crystals. Melting Point: 146.5 ℃, Boiling Point: 267-270 ℃(99kPa). Soluble in dilute acid, soluble in alcohol, ether and hot water. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | NK7745000 |
HS Code | 29339990 |
Reference Show more | Xie Dani hoedan-si. Synthesis and characterization of two N-Heterocyclic Carbene Pd(Ⅱ) complexes [J]. Journal of Tianjin University of Science and Technology 2018 33(3). |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Uses | Indazole is an important organic synthesis intermediate, and many of its derivatives have pharmaceutical activity. For example, the indazole ring reacts with arylboric acid under the catalysis of Cu(Ⅱ) to obtain 1-arylindazole, and 1-arylindazole can be used as a contraceptive; indazole reacts with acid anhydride or acid chloride to obtain N-Acyl indazole, some of which N-acylindazole has deworming activity. Used in organic synthesis. |
Production method | First, 3-chloroindazole is obtained from anthranilic acid through diazotization, reduction, cyclization, and chlorination. Then, 3-chloroindazole, red phosphorus and hydroiodic acid were mixed and refluxed for 24h, and then refined after treatment to obtain indazole. |