Molecular Formula | C7H6N4O2 |
Molar Mass | 178.15 |
Density | 1.68±0.1 g/cm3(Predicted) |
Melting Point | 220°C dec. |
Boling Point | 493.6±28.0 °C(Predicted) |
Solubility | DMSO:40 mg/mL |
Appearance | Shape powder, color orange to dark orange-red |
pKa | 1.51±0.30(Predicted) |
Storage Condition | -20°C |
Physical and Chemical Properties | Bioactive Tirapazamine (NSC 130181, SR 259075, SR 4233, Tirazone, WIN 59075) is a new anticancer drug for solid tumors. Tirapazamine showed preferential tumor cell lethality and high specific toxicity to cells under hypoxic tension. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | DM0671500 |
Reference Show more | 1. [IF=15.621] Yanke Wang et al."Functionalized Holmium‐Doped Hollow Silica Nanospheres for Combined Sonodynamic and Hypoxia‐Activated Therapy."Adv Funct Mater. 2019 Jan;29(3):1805764 2. [IF=8.456] Yeneng Dai et al."Multifunctional Theranostic Liposomes Loaded with a Hypoxia-Activated Prodrug for Cascade-Activated Tumor Selective Combination Therapy."Acs Appl Mater Inter. 2019;11(43):39410–39423 |