2799-16-8
(R)-(-)-1-aminopropan-2-ol
CAS: 2799-16-8
Molecular Formula: C3H9NO
2799-16-8 - Names and Identifiers
| Name | (R)-(-)-1-aminopropan-2-ol |
| Synonyms | (?)-Isopropanolamine (2R)-1-Aminopropan-2-ol (2R)-1-Amino-2-propanol (R)-1-Aminopropane-2-ol (R)-(-)-Isopropanolamine 2-Propanol, 1-amino-, (R)- (R)-(-)-1-AMINO-2-PROPANOL (R)-(-)-1-aminopropan-2-ol (R)-(?)-1-Amino-2-propanol (R)-1-(Aminomethyl)ethanol (R)-(-)-1-Amino-2-propanol (2R)-(-)-1-Aminopropan-2-ol (2R)-(-)-1-Amino-2-propanol (2R)-(-)-2-Hydroxypropylamine, (2R)-(-)-1-Amino-2-hydroxypropane |
| CAS | 2799-16-8 |
| EINECS | 220-532-9 |
| InChI | InChI=1/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3/t3-/m1/s1 |
| InChIKey | HXKKHQJGJAFBHI-GSVOUGTGSA-N |
2799-16-8 - Physico-chemical Properties
| Molecular Formula | C3H9NO |
| Molar Mass | 75.11 |
| Density | 0.954 g/mL at 25 °C (lit.) |
| Melting Point | 24-26 °C (lit.) |
| Boling Point | 160 °C (lit.) |
| Specific Rotation(α) | -18 º (c=1.8, H2O) |
| Flash Point | 165°F |
| Water Solubility | soluble |
| Vapor Presure | <1 mm Hg ( 20 °C) |
| Vapor Density | 2.6 (vs air) |
| Appearance | Liquid After Melting |
| Specific Gravity | 0.954 |
| Color | Clear colorless to light yellow |
| BRN | 1718869 |
| pKa | 12.92±0.35(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Sensitive | Hygroscopic |
| Refractive Index | n20/D 1.4482(lit.) |
2799-16-8 - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3259 8/PG 2 |
| WGK Germany | 1 |
| RTECS | UA5775000 |
| FLUKA BRAND F CODES | 10-34 |
| HS Code | 29221990 |
| Hazard Class | 8 |
| Packing Group | III |
2799-16-8 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Uses | (R)-(-)-1-amino-2-propanol, as an important synthetic intermediate, is widely used in the preparation of medicines and pesticides. Chiral compound (R)-1-amino-2-propanol is an important intermediate for the synthesis of nucleoside drugs (such as the anti-AIDS drug tenofovir). |
| preparation | 290g of acetone and 1g of glacial acetic acid are added into the three-mouth bottle at room temperature, 35g of ammonia is introduced and stirred for 4h, 58g(R)-( )-1,2-propylene oxide are added dropwise into the reaction bottle, after dropping, heated and refluxed, reacted for 2h, and the excess acetone is distilled under reduced temperature, the crude product was hydrolyzed by adding 800g dilute hydrochloric acid (dilute hydrochloric acid concentration is 5wt%) directly, stirring at room temperature for 30min, adding sodium hydroxide aqueous solution (concentration of sodium hydroxide aqueous solution is 10wt%) to adjust pH = 10, distillate filtrate under reduced pressure, and distillate 56g of product with 74.66% yield. The content of (R)-(-)-1-amino -2-propanol was> 99wt% by gas chromatography. |
| spontaneous combustion temperature | 635 °F |
Last Update：2024-04-09 15:16:45
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