| Molecular Formula | C10H13ClN2S |
| Molar Mass | 228.74 |
| Physical and Chemical Properties | The pure chemical product is white needle-like crystal. M. p.175 ℃, vapor pressure 1.0666 × 10-6Pa(20 ℃). It can be slightly soluble in a variety of organic solvents, and its solubility in water is 50mg/L at 20 ℃. |
| Use | The use of substituted urea insecticides. For the immersion of cattle, sheep, horses, dogs, prevention and control of all kinds of ticks, but also to control the other acaricide resistant ticks. |
Toxicity
The acute oral LD50 of the original drug to rats is 2500mg/kg, and the acute percutaneous LD50 is 21500mg/kg.
production method
Preparation method I
preparation of p-chloro-toluidine hydrochloride 0.25mol o-toluidine is mixed with 125mL nitrobenzene, acetic anhydride is added dropwise, after 2 hours of reaction, cooling and chlorine passing, and stopping chlorine passing after a large amount of white solid appears. Add 10.5mL of concentrated hydrochloric acid and 28mL of water, gradually heat, stir for 4 hours, dissolve the solid, cool and filter, wash with a little nitrobenzene, and dry to obtain 36.8g of p-chloro-toluidine salt with 82.1% yield.
synthesis of insecticide 0.1mol p-chloro-toluidine hydrochloride, 56mL nitrobenzene, 4.5g sodium hydroxide and 16mL are mixed, heated to 80~85 ℃, and the solid is dissolved. Cooling, dropping 0.2mol of carbon disulfide at room temperature, then cooling to 1 ℃, dropping 24mL of 33% dimethylamine aqueous solution, the reaction is exothermic, the solid is dissolved, the reflux reaction is 5 hours, cooling, suction filtration, filter cake is washed with nitrobenzene, then washed with water and dried to obtain 18.9g of yellow solid with 81.8% yield. Pure products can be obtained after recrystallization.
Preparation method II
The direct reaction of isothiocyanate and dimethylamine is used to obtain dianuron, which
category
Pesticides
toxicity classification
Poisoning
acute toxicity
oral-rat LD50: 2500 mg/kg
flammability hazard characteristics
Flammable; combustion produces toxic nitrogen oxides, sulfur oxides and chloride gases
storage and transportation features
The warehouse is ventilated and dry at low temperature; stored and transported separately from food raw materials
fire extinguishing agent
Dry powder, foam, sand