28229-69-8
3-Bromophenethylalcohol
CAS: 28229-69-8
Molecular Formula: C8H9BrO
28229-69-8 - Names and Identifiers
| Name | 3-Bromophenethylalcohol |
| Synonyms | m-bromobenzeneethanol 3-bromobenzeneethanol 3-Bromophenethylacohol 3-Bromophenethylalcohol 3-BROMOPHENETHYL ALCOHOL 2-(3-BROMOPHENYL)ETHANOL 3-bromophenethyl alcohol 2-(3-Bromophenyl)-ethanol 3-BROMOPHENYLETHYL ALCOHOL 2-(3-Bromophenyl)ethan-1-ol 2-(3-Bromophenyl)ethyl Alcohol |
| CAS | 28229-69-8 |
| EINECS | 691-780-7 |
| InChI | InChI=1/C8H9BrO/c9-8-3-1-2-7(6-8)4-5-10/h1-3,6,10H,4-5H2 |
28229-69-8 - Physico-chemical Properties
| Molecular Formula | C8H9BrO |
| Molar Mass | 201.06 |
| Density | 1.478 g/mL at 25 °C (lit.) |
| Boling Point | 107-110 °C/1 mmHg (lit.) |
| Flash Point | >230°F |
| Vapor Presure | 0.00259mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless |
| pKa | 14.83±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.5732(lit.) |
28229-69-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29062990 |
| Hazard Note | Harmful/Irritant/Keep Cold |
28229-69-8 - Reference Information
| overview | 3-bromophenylethanol is an alcohol derivative and can be used as an intermediate in pharmaceutical synthesis. |
| preparation method | preparation method of 3-bromobenzene ethanol: 1) react m-bromobenzene acetic acid with ethanol to obtain compound 1: mix 0.1mol m-bromobenzene acetic acid with 300mL absolute ethanol, and then add 20mL concentrated sulfuric acid (concentrated sulfuric acid as catalyst) dropwise. After complete addition, the reaction mixture is heated (heated to the boiling point of the solvent, here is the boiling point of ethanol 78°C) to reflux for 5 hours. Add 100mL of water to the reaction solution, stir 200mL of petroleum ether for 10 minutes, separate the organic phase and extract the aqueous phase twice with petroleum ether, merge the organic phase, wash the water to neutral, dry, and remove the solvent under reduced pressure to obtain compound 1 with 100% yield and 99.8% purity. 2) Compound 1 is reduced to obtain Compound 2: 0.2mol potassium borohydride, 0.2mol anhydrous lithium chloride and 300mL tetrahydrofuran are mixed, externally cooled with ice water, and 0.1mol compound 1 and 150mL tetrahydrofuran are added dropwise. After complete addition, the reaction mixture is heated to reflux, reacted for 8-20 hours, and monitored until the raw material reaction is complete. Slowly pour the reaction solution into 1Kg of crushed ice and 500mL of water, add 200mL of toluene and stir for 10 minutes, separate the organic phase and extract the aqueous phase twice with toluene, merge the organic phase, wash to neutral, dry, and evaporate the solvent under reduced pressure. Petroleum ether was recrystallized to obtain compound 2 (3-bromophenylethanol) with 95% yield and 99.6% purity. |
Last Update：2024-04-09 20:49:11
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Tel: +86-18821248368
Email: Int06@meryer.com
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QQ: 495145328
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