286930-02-7

Name	2-Methylpropionic acid 2-[3-(N,N-diisopropylamino)-1(R)-phenylpropyl]-4-(hydroxymethyl)phenyl ester
Synonyms	SPM-907 PF-00695838 Fesoterodine (R) Fesoterodine (R)-Fesoterodine 2-Methylpropionic acid 2-[3-(N,N-diisopropylamino)-1(R)-phen... (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate Isobutyric acid 2-[3-(diisopropylamino)-1(R)-phenylpropyl]-4-(hydroxymethyl)phenyl ester 2-Methylpropionic acid 2-[3-(N,N-diisopropylamino)-1(R)-phenylpropyl]-4-(hydroxymethyl)phenyl ester 2-Methylpropanoic acid 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester Propanoic Acid 2-Methyl- 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl Ester
CAS	286930-02-7

Molecular Formula	C26H37NO3
Molar Mass	411.58
Density	1.043
Storage Condition	2-8℃
In vitro study	Fesoterodine decreases micturition frequency, urgency severity and urgency incontinence episodes and increases the volume voided with each micturition. After oral administration, Fesoterodine is rapidly and extensively hydrolysed in plasma by nonspecific esterases to Desfesoterodine (5-hydroxymethyl tolterodine; SPM 7605; HY-76569; an active metabolite of Fesoterodine).

Last Update：2024-01-02 23:10:35

overview	frostidine (fesoterodine, trade name ToviazTM) is a new type of m receptor blocker, which is rapidly metabolized into active metabolites in the body and plays a role.
use	Frostine was approved by FDA on October 31, 2008 for the treatment of overactive bladder (overactivebladder,OAB).
Biological activity	Fesoterodine is an orally effective, non-subtype selective, competitive muscarinic receptor (mAChR) antagonist. The pKi values for M1,M2,M3,M4,M5 receptors are 8.0,7.7,7.4,7.3,7.5, respectively. Fesoterodine for overactive bladder (OAB).
target	pKi: 8.0 (M1), 7.7 (M2), 7.4 (M3), 7.3 (M4) and 7.5 (M5)
Animal Model:	Bladders from female Sprague-Dawley rats (225-275 g)
Dosage:	0.01, 0.1 and 1 mg/kg
Administration:	IV
Result:	Reduced the micturition pressure and increased bladder capacity and ICIs at the lowest dose tested of 0.01 mg/kg.

Last Update：2024-04-09 15:16:49

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286930-02-7

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