286946-77-8
5-Bromo-2-chloro-pyridin-3-ol
CAS: 286946-77-8
Molecular Formula: C5H3BrClNO
286946-77-8 - Names and Identifiers
| Name | 5-Bromo-2-chloro-pyridin-3-ol |
| Synonyms | CML-034 5-bromo-2-chloropyridin-3-o 5-Bromo-2-chloropyridin-3-ol 5-BROMO-2-CHLORO-PYRIDIN-3-OL 5-Bromo-2-chloro-pyridin-3-ol 3-Pyridinol, 5-bromo-2-chloro- 3-pyridinol, 5-bromo-2-chloro- 2-Chloro-3-hydroxy-5-broMopyridine 5-Bromo-2-chloro-3-hydroxypyridine 5-Bromo-2-chloro-2-hydroxypyridine |
| CAS | 286946-77-8 |
| InChI | InChI=1/C5H3BrClNO/c6-3-1-4(9)5(7)8-2-3/h1-2,9H |
| InChIKey | KVDIPLHFSIUSIK-UHFFFAOYSA-N |
286946-77-8 - Physico-chemical Properties
| Molecular Formula | C5H3BrClNO |
| Molar Mass | 208.44 |
| Density | 1.908±0.06 g/cm3(Predicted) |
| Melting Point | 182-183 °C |
| Boling Point | 338.1±37.0 °C(Predicted) |
| Flash Point | 158.27°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 3.54±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.629 |
| MDL | MFCD08688592 |
286946-77-8 - Risk and Safety
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
286946-77-8 - Introduction
It is an organic compound with the chemical formula C5H3BrClNO. The following is a description of its nature, use, preparation and safety information:
Nature:
-is a white solid, soluble in organic solvents such as methanol and methylene chloride.
-It is stable in the air and will decompose at high temperatures.
-The compound is toxic, especially irritating and corrosive to the respiratory system and eyes.
Use:
-is often used as an important intermediate in organic synthesis.
-It can be used to synthesize biologically active compounds, such as drugs and pesticides.
Method:
There are many methods of synthesis, one of which is commonly used by Bromination and chlorination.
-First, pyridine is reacted with bromine and chlorinating agent. Under suitable reaction conditions, Bromination and chlorination reactions will occur to produce 2-chloro-5-bromopyridine.
-Next, react 2-chloro-5-bromopyridine with a base or an electrophile to generate a pyridine.
Safety Information:
-has a certain toxicity, Operation should pay attention to safety.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
-Wear appropriate personal protective equipment such as gloves, goggles and protective clothing during operation.
-During storage and handling, avoid contact with oxidants and combustibles, and keep away from open flames and high temperature environments.
Nature:
-is a white solid, soluble in organic solvents such as methanol and methylene chloride.
-It is stable in the air and will decompose at high temperatures.
-The compound is toxic, especially irritating and corrosive to the respiratory system and eyes.
Use:
-is often used as an important intermediate in organic synthesis.
-It can be used to synthesize biologically active compounds, such as drugs and pesticides.
Method:
There are many methods of synthesis, one of which is commonly used by Bromination and chlorination.
-First, pyridine is reacted with bromine and chlorinating agent. Under suitable reaction conditions, Bromination and chlorination reactions will occur to produce 2-chloro-5-bromopyridine.
-Next, react 2-chloro-5-bromopyridine with a base or an electrophile to generate a pyridine.
Safety Information:
-has a certain toxicity, Operation should pay attention to safety.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
-Wear appropriate personal protective equipment such as gloves, goggles and protective clothing during operation.
-During storage and handling, avoid contact with oxidants and combustibles, and keep away from open flames and high temperature environments.
Last Update：2024-04-09 21:01:54
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CAS: 286946-77-8
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CAS: 286946-77-8
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