28797-48-0

28797-48-0 - Names and Identifiers

Name	11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Synonyms	N'-(2-chloro-3-pyridinyl)-N,N-dimethylmethanimidamide 11-(CHLOROACETYL)-5,11-DIHYDRO-6H-PYRIDO[3,2-C][2]BENZAZEPIN-6-ONE 11-(2-Chloroacetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one 1-(2-Chloroacetyl)-5,11-dihydro-pyrido[2,3-b][1,4]benzodiazepin-6-one 5,11-Dihydro-11-Chloroacetyl-6H-Pyrido[2,3-B][1,4]Benzodiazepin-6-One 5,11-DIHYDRO-11-CHLOROACETYL-6H-PYRIDOP2,3-B][1,4]BENZODIAZEPINE-6-ONE 5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 11-(2-Chloroacetyl)-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one 5,11-dihydro-11-chloroacetyl-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one(DCPBO) 5,11-DIHYDRO-11-CHLOROACETYL-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPINE-6-ONE[INTERMEDIATES OF PIRENZEPINE]
CAS	28797-48-0
EINECS	249-227-9
InChI	InChI=1/C14H10ClN3O2/c15-8-12(19)18-11-6-2-1-4-9(11)14(20)17-10-5-3-7-16-13(10)18/h1-7H,8H2,(H,17,20)

28797-48-0 - Physico-chemical Properties

Molecular Formula	C14H10ClN3O2
Molar Mass	287.7
Density	1.415
Boling Point	481.1°C at 760 mmHg
Flash Point	244.7°C
Vapor Presure	2.06E-09mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.637

28797-48-0 - Introduction

11-(chloroacetyl)-5,11-dihydro-6h-pyrido [2,3-b][1,4]benzodiazepin-6-one is an organic compound with multiple hydrogen bonds and a heterocyclic structure. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
-Appearance: White solid
-Molecular formula: C17H11ClN2O2
-Molecular weight: 316.73g/mol
-Melting point: about 160-162 ° C
-Solubility: Soluble in organic solvents such as chloroform, dimethyl sulfoxide and dichloromethane, insoluble in water.

Use:
11-(choroacetyl)-5,11-dihydro-6h-pyrido [2,3-b][1,4]benzodiazepin-6-one is an effective intermediate commonly used in the synthesis of drugs and pesticides. Its derivatives have a wide range of biological activities and can be used in the research and development of anti-cancer, anti-virus and other drugs.

Method:
A common synthesis method is to obtain 5 by reacting chloroacetic acid with the corresponding 1,4-diazepine, 11-Dihydro-6H-pyrido [2.3-B][1,4] benzodiazepin-6-one, which is then reacted with Chloroacetyl Chloride to give the desired product. The specific preparation method can refer to the relevant research literature or patent documents.

Safety Information:
When handling 11-(chloroacetyl)-5,11-dihydro-6h-pyrido [2,3-b][1,4]benzodiazepin-6-one, the following safety measures should be observed:
-Avoid contact with skin, eyes and respiratory tract. In case of accidental contact or inhalation, rinse immediately with plenty of water and seek medical help.
-Wear suitable personal protective equipment such as protective gloves, glasses and face shields during operation.
-Avoid open flames and high temperature conditions to prevent the risk of burning and explosion.
-Storage should be sealed and kept away from fire and oxidizing agents.
-If there is no training or proper laboratory conditions, synthesis and use are not recommended. Consult a professional and follow the relevant laboratory safety procedures before operating.

Last Update：2024-04-09 19:05:48