2881-63-2
3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
CAS: 2881-63-2
Molecular Formula: C11H11ClO3
2881-63-2 - Names and Identifiers
2881-63-2 - Physico-chemical Properties
| Molecular Formula | C11H11ClO3 |
| Molar Mass | 226.66 |
| Density | 1.218g/mLat 25°C(lit.) |
| Melting Point | 38 °C(Solv: ethanol (64-17-5)) |
| Boling Point | 268-269°C(lit.) |
| Flash Point | >230°F |
| Solubility | soluble in Acetone |
| Vapor Presure | 0.000476mmHg at 25°C |
| Appearance | powder to lump |
| Color | White to Orange to Green |
| pKa | 9.56±0.25(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.5500(lit.) |
2881-63-2 - Risk and Safety
| WGK Germany | 3 |
2881-63-2 - Reference Information
| Preparation | Ethyl 3-(4-chlorophenyl)-3-oxo-propionate can be prepared from 4-chlorobenzoic acid. Oxalyl chloride (25mL, 0.288mol) was added to a solution of 4-chlorobenzoic acid (30.0g,0.192mol) in DCM (250mL), and DMF (0.5mL) was added dropwise. The reaction mixture was refluxed for 2 hours. The obtained clear yellow solution was concentrated under vacuum to obtain the acid chloride as the yellow liquid. TEA (67mL) was added to a solution of potassium ethyl malonate (41g,0.241mol) in acetonitrile (537mL). After cooling in an ice-salt bath, MgCl2 (27.4g,0.288mol) was added and the resulting mixture was stirred at this temperature for 3 hours. The acid chloride (prepared as described above) is added, and the reaction mixture is heated to ambient temperature and stirred overnight. Cool the mixture in an ice bath and carefully add 2N HCl (600mL). The mixture was stirred in an ice bath for 1.5 h and then transferred to a separatory funnel and extracted with ethyl acetate (3 × 200mL). The combined organic layer was washed with saturated sodium bicarbonate (450mL) and brine (250mL), dried with anhydrous sodium sulfate, filtered, and concentrated in vacuum to obtain the crude product 3-(4-chlorophenyl)-3-oxo-ethyl propionate (48.6g), which does not require purification. |
| Uses | Ethyl 3-(4-chlorophenyl)-3-oxo-propionate is a carboxylate organic substance and can be used as a pharmaceutical intermediate. There are reports that it can be used to prepare BET inhibitors. |
Last Update：2024-04-09 21:00:56
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Product Name: 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Visit Supplier Webpage Request for quotationCAS: 2881-63-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Request for quotation
CAS: 2881-63-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
CAS: 2881-63-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380
Wechat: 15387090420
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