288401-62-7

288401-62-7 - Names and Identifiers

Name	(6E)-4-fluoro-6-isoxazol-5(2H)-ylidenecyclohexa-2,4-dien-1-one
Synonyms	4-FLUORO-2-(5-ISOXAZOLYL)PHENOL 4-FLUORO-2-(ISOXAZOL-5-YL)PHENOL Phenol, 4-fluoro-2-(5-isoxazolyl)- 5-(5-FLUORO-2-HYDROXYPHENYL)ISOXAZOLE 4-fluoro-6-(2H-isoxazol-5-ylidene)-1-cyclohexa-2,4-dienone (6E)-4-fluoro-6-isoxazol-5(2H)-ylidenecyclohexa-2,4-dien-1-one (6E)-4-fluoro-6-(2H-1,2-oxazol-5-ylidene)cyclohexa-2,4-dien-1-one
CAS	288401-62-7
InChI	InChI=1/C9H6FNO2/c10-6-1-2-8(12)7(5-6)9-3-4-11-13-9/h1-5,11H/b9-7+

288401-62-7 - Physico-chemical Properties

Molecular Formula	C9H6FNO2
Molar Mass	179.15
Density	1.38g/cm³
Melting Point	188-192°C(lit.)
Boling Point	245.6°C at 760 mmHg
Flash Point	102.3°C
Solubility	soluble in Methanol
Vapor Presure	0.0284mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
Storage Condition	Room Temprature
Refractive Index	1.599

288401-62-7 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

288401-62-7 - Introduction

(6E)-4-fluoro-6-isoxazol-5(2H)-ylidenecyclohexa-2,4-dien-1-one is an organic compound with the chemical formula C11H7FNO2S. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance:(6E)-4-fluoro-6-isoxazol-5(2H)-ylidenecyclohexa-2,4-dien-1-one as a yellow solid.
-Melting point: The melting point of this compound is approximately in the range of 130-132°C.
-Solubility: It has good solubility in common organic solvents.

Use:
-Drug Research:(6E)-4-fluoro-6-isoxazol-5(2H)-ylidenecyclohexa-2,4-dien-1-one and its derivatives are widely used in the field of drug research, such as for the design and synthesis of new biologically active compounds.
-Antibacterial drug: It is also used as an intermediate of antibacterial drugs for the synthesis of new antibacterial agents.

Method: The preparation method of
(6E)-4-fluoro-6-isoxazol-5(2H)-ylidenecyclohexa-2,4-dien-1-one is more complicated, and usually requires multiple reactions. A common synthesis method is: first, benzoic acid and aminothiazole are reacted by chemical reaction to form benzoylaminothiazole, and then the final target product is obtained by multiple chemical transformations.

Safety Information:
- (6E)-4-fluoro-6-isoxazol-5(2H)-ylidenecyclohexa-2, the safety and toxicity of 4-dien-1-one have not been fully determined, so you need to be cautious during use and follow the laboratory Safety operating procedures.
-In contact and inhalation should pay attention to avoid direct skin contact and inhalation, and it is best to operate in a well-ventilated place, and equipped with appropriate personal protective equipment.
-Any working waste associated with the compound must be safely handled and disposed of in accordance with local regulations.

Last Update：2024-04-09 21:32:39