289039-85-6

289039-85-6 - Names and Identifiers

Name	Methyl 3-chloro-5-iodobenzoate
Synonyms	METHYL 3-CHLORO-5-IODOBENZOATE Methyl 3-chloro-5-iodobenzoate 3-chloro-5-iodobenzoic acid methyl ester benzoic acid, 3-chloro-5-iodo-, methyl ester Benzoic acid, 3-chloro-5-iodo-, methyl ester
CAS	289039-85-6
InChI	InChI=1/C8H6ClIO2/c1-12-8(11)5-2-6(9)4-7(10)3-5/h2-4H,1H3

289039-85-6 - Physico-chemical Properties

Molecular Formula	C8H6ClIO2
Molar Mass	296.49
Density	1.837±0.06 g/cm3(Predicted)
Melting Point	41-43°C
Boling Point	322.7±27.0 °C(Predicted)
Flash Point	149°C
Vapor Presure	0.000275mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Sensitive	Light Sensitive
Refractive Index	1.608
MDL	MFCD00673018

289039-85-6 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection

289039-85-6 - Introduction

Methyl 3-chloro-5-iodobenzoate is an organic compound with the chemical formula C8H6CIO2. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless to slightly yellow crystalline solid
-Melting point: 60-62 degrees Celsius
-Boiling Point: Not Applicable
-Density: 1. 94g/cm3
-Stability: stable at room temperature, but avoid contact with strong oxidants

Use:
- Methyl 3-chroo-5-iodobenzoate is used as an intermediate in organic synthesis and is often used to synthesize compounds with medicinal activity.
-It can be used as a raw material for pesticides, insecticides and antibiotics.

Method:
Methyl 3-chloro-5-iodobenzoate can be synthesized by the following steps:
1. Iodobenzoic acid and sodium nitrite were reacted under the catalysis of sulfuric acid to obtain 2-nitrobenzoic acid.
2. 2-nitrobenzoic acid and thionyl chloride are reacted at low temperature to obtain 3-nitrobenzoic acid.
3. 2-Nitrobenzoic acid and 2,4, 6-trichlorotoluene were reacted under acidic conditions to obtain 3-chloro-5-nitrobenzoic acid.
4. Under acidic conditions, iodic acid reacts with 3-chloro-5-nitrobenzoic acid to generate 3-chloro-5-iodobenzoic acid.
5. Finally, 3-chloro-5-iodobenzoic acid is reacted with methanol to produce Methyl 3-chloro-5-iodobenzoate.

Safety Information:
- Methyl 3-chloro-5-iodobenzoate is an organic compound, which has certain toxicity and should be operated with caution.
-Contact with skin, eyes or inhalation of vapors may cause irritation and direct contact should be avoided.
-Take appropriate precautions during handling or use, such as wearing appropriate gloves, goggles and protective clothing.
-When the treatment is completed, the waste should be disposed of correctly to avoid pollution or harm to the environment.
-in the use of the process, should strictly abide by the relevant safety procedures.

Last Update：2024-04-10 22:29:15