Name | Procyanidin B2 |
Synonyms | Procyanidin B2 PROCYANIDIN B2 4,8'-BI-[(+)-EPICATECHIN] EPICATECHIN(4B-8)EPICATECHIN CIS,CIS'-4,8'-BI(3,3',4',5,7-PENTAHYDROXYFLAVANE) 4,8-Bi-[(+)-epicatechin], cis,cis-4,8-Bi(3,3μ,4μ,5,7-pentahydroxyflavane) (2R,2'R,3R,3'R,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-4,8'-bichroman-3,3',5,5',7,7'-hexol |
CAS | 29106-49-8 |
InChIKey | XFZJEEAOWLFHDH-NFJBMHMQSA-N |
Molecular Formula | C30H26O12 |
Molar Mass | 578.52 |
Density | 1.705 |
Melting Point | 197-198℃ |
Boling Point | 955.3±65.0 °C(Predicted) |
Specific Rotation(α) | +26 (H2O) |
Solubility | DMSO : ≥ 50 mg/mL (86.43 mM) |
Appearance | Off-white to gray (Solid) |
Color | Light Red to Brown |
pKa | 9.29±0.60(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
MDL | MFCD01861513 |
Physical and Chemical Properties | From grape seed |
Use | It has the effects of protecting cardiovascular, preventing hypertension, anti-tumor, anti-radiation, anti-mutation and beauty. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
Plant Source: | grape seed |
Overview | Anthocyanidins are water-soluble pigments that change color with the acid-base of the cell fluid. The cytosol was acidic and red, while the cytosol was alkaline and blue. Anthocyanin is one of the main pigments that make up the color of petals and fruits. Generation via the phenylpropionic acid synthesis pathway and the flavonoid biosynthesis pathway. The factors that affect the color of anthocyanins include the structure of anthocyanins, pH value, and the effect of the color (co). Pericarp coloration is influenced by intrinsic and extrinsic factors and cultivation techniques. Light can increase anthocyanin content; High temperature will cause degradation of anthocyanin. Anthocyanins are secondary metabolites of plants, which play an important role in physiology. |
Source | seeds of Vitis vinifera L. |
pharmacological effects | with cardiovascular protection, prevention of hypertension, anti-tumor, anti-radiation, anti-mutation and cosmetic effects. |
the content of proanthocyanidins in grape seed extract is determined by proanthocyanidins B2 | proanthocyanidins are a class of substances, they are composed of catechins, epicatechin and its gallic acid ester are covalently linked by C4-C6 or C4-C8 bonds. The main component of grape seed extract is proanthocyanidins, determination of the content of total proanthocyanidins is one of the main indicators to measure its quality. proanthocyanidin B2 is the standard method for the determination of proanthocyanidin in grape seed extract. The content of proanthocyanidin B2(HPLC calibration) with the content of 99% or more was used as the standard, and the absorbance was measured at 546 nm with reference to the Bate-Smith method to calibrate the content of proanthocyanidin in the grape seed extract. The absorbance of proanthocyanidin B2 reacted by Bate-Smith method had a good linear relationship with the concentration, and the linear range was 22.89 μg/mL ~ 114.5 μg/mLr,= 0.999 02(n = 5). Recovery Rate: 97.99%,RSD: 1.02%(n = 6). In this method, the single component B2 of proanthocyanidin calibrated by HPLC is used as the standard, which solves the problem that the standard of proanthocyanidin content of proanthocyanidin mixture is not uniform and cannot be convincing, the determination results can accurately reflect the true content of proanthocyanidins in grape seed extract, and can be used as a quality control method. [author]: Tianjin Jianfeng Natural Products Research and Development Co., Ltd. [author]: Wu Wei, Cheng, Xiu, Feng, Wang, Cui, Chunhui, Wenxi, Fu, fluorescence |
uses | for content determination/identification/pharmacological experiments and other pharmacological effects: with the protection of cardiovascular, prevention of hypertension, anti-tumor, anti-radiation, anti-mutation and cosmetic effects. |