292168-79-7
KY1220
CAS: 292168-79-7
Molecular Formula: C14H10N4O3S
292168-79-7 - Names and Identifiers
| Name | KY1220 |
| Synonyms | KY1220 KY-1220 KY 1220 292168-79-7 4-Imidazolidinone, 5-[[1-(4-nitrophenyl)-1H-pyrrol-2-yl]methylene]-2-thioxo- |
| CAS | 292168-79-7 |
292168-79-7 - Physico-chemical Properties
| Molecular Formula | C14H10N4O3S |
| Molar Mass | 314.32 |
| Solubility | DMSO: ≥100 mg/mL |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| In vitro study | KY1220 shows an IC 50 of 2.1 μM in HEK293 reporter cells. KY1220 dose dependently decreases Wnt3a-CM-induced TOPflash reporter activation and mRNA expression of Wnt target genes CCND1 and MYC in HEK293 cells. In HEK293 cells, both β-catenin and panRas protein levels are similarly reduced in a dose-dependent manner after treatment with KY1220, whereas the mRNA levels of CTNNB1 (which encodes β-catenin), NRAS, KRAS and HRAS remain unchanged. K-Ras, which has a critical role in progression of CRCs, is also destabilized by KY1220 via polyubiquitin-dependent proteasomal degradation. KY1220 accelerates the degradation rates of both β-catenin and Ras in SW480 cell lines. Ras destabilization by KY1220 consequently inhibits the activities of both ERK and Akt, which are downstream effectors of Ras in SW480 cells harboring a KRAS mutation. The proliferation and transformation of the HCT15, SW480, D-WT and D-MT CRC cells are efficiently inhibited after treatment with KY1220. |
292168-79-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.181 ml | 15.907 ml | 31.815 ml |
| 5 mM | 0.636 ml | 3.181 ml | 6.363 ml |
| 10 mM | 0.318 ml | 1.591 ml | 3.181 ml |
| 5 mM | 0.064 ml | 0.318 ml | 0.636 ml |
Last Update：2024-01-02 23:10:35
292168-79-7 - Introduction
KY1220 is a chemical substance whose chemical name is 2-pentyl-1, 3-benzenediol. The following is an introduction to the nature, use, preparation and safety information of KY1220:
Nature:
-Appearance: KY1220 is white crystalline powder or granular solid.
-Solubility: KY1220 soluble in organic solvents such as ethanol, ether and ketone, insoluble in water.
-Stability: KY1220 is relatively stable at room temperature and can be stored for a long time under dry, dark and sealed conditions.
Use:
- KY1220 is commonly used as an intermediate for important phenolic resins in the chemical industry. These phenolic resins can be used to make plastics, rubbers, polymeric materials, etc.
- KY1220 can also be used in the field of synthetic dyes, drugs and coatings.
Preparation Method:
- KY1220 can be prepared by the condensation reaction of phenol and valeraldehyde. The reaction process needs to be carried out under acidic conditions and uses an acidic catalyst.
Safety Information:
- KY1220 belongs to chemicals and needs to pay attention to safe operation before use. Wear appropriate personal protective equipment such as chemical goggles and gloves.
- KY1220 is an irritant substance. Avoid inhaling, touching the skin or getting into the eyes.
-In the event of accidental ingestion or exposure, rinse immediately with plenty of water and seek prompt medical help.
Please note that the above information is for reference only. When using KY1220 or other chemical substances, the relevant safety data sheets and operating instructions should be carefully read, and the safety regulations of the laboratory should be strictly followed.
Nature:
-Appearance: KY1220 is white crystalline powder or granular solid.
-Solubility: KY1220 soluble in organic solvents such as ethanol, ether and ketone, insoluble in water.
-Stability: KY1220 is relatively stable at room temperature and can be stored for a long time under dry, dark and sealed conditions.
Use:
- KY1220 is commonly used as an intermediate for important phenolic resins in the chemical industry. These phenolic resins can be used to make plastics, rubbers, polymeric materials, etc.
- KY1220 can also be used in the field of synthetic dyes, drugs and coatings.
Preparation Method:
- KY1220 can be prepared by the condensation reaction of phenol and valeraldehyde. The reaction process needs to be carried out under acidic conditions and uses an acidic catalyst.
Safety Information:
- KY1220 belongs to chemicals and needs to pay attention to safe operation before use. Wear appropriate personal protective equipment such as chemical goggles and gloves.
- KY1220 is an irritant substance. Avoid inhaling, touching the skin or getting into the eyes.
-In the event of accidental ingestion or exposure, rinse immediately with plenty of water and seek prompt medical help.
Please note that the above information is for reference only. When using KY1220 or other chemical substances, the relevant safety data sheets and operating instructions should be carefully read, and the safety regulations of the laboratory should be strictly followed.
Last Update：2024-04-09 19:05:02
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Spot supply
Product Name: KY1220 Visit Supplier Webpage Request for quotationCAS: 292168-79-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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