Molecular Formula | C10H8O3 |
Molar Mass | 176.17 |
Density | 1.384±0.06 g/cm3(Predicted) |
Melting Point | 111-113 °C (lit.) |
Boling Point | 365.0±41.0 °C(Predicted) |
pKa | 3.67±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
RTECS | NK8260000 |
Hazard Note | Irritant |
use | 3-carbonyl -1-indenoic acid can be used as an intermediate in pharmaceutical synthesis. |
preparation | phenylsuccinic anhydride (10g,57mmol) is dissolved in 1,2-dichloroethane (200mL) and then added dropwise to 1,2-dichloroethane (50mL) solution of aluminum trichloride (17g,130mmol) at 0°C, after dropping, continue stirring at room temperature for 1 hour, then add water (50mL) at 0°C for quenching, and ethyl acetate extraction (3X?60mL), the organic phase was evaporated to obtain 3-carbonyl -2,3-dihydro-1H-indene -1-formic acid (3-carbonyl -1-indene acid), which was 8.3g of light yellow oily product with 83% yield). |