2957-21-3
Sakuranetin
CAS: 2957-21-3
Molecular Formula: C16H14O5
2957-21-3 - Names and Identifiers
| Name | Sakuranetin |
| Synonyms | SAKURANETIN Sakuranetin SAKURANETIN(SH) SAKURANETIN hplc 4',5-DIHYDROXY-7-METHOXYFLAVANONE 5,4''-DIHYDROXY-7-METHOXYFLAVANONE 5,4'-DIHYDROXY-7-O-METHOXYFLAVANONE 5,4''-DIHYDROXY-7-METHOXYFLAVANONE WITH HPLC 5,4''-DIHYDROXY-7-METHOXYFLAVANONE MONOHYDRATE WITH HPLC |
| CAS | 2957-21-3 |
| EINECS | 220-980-5 |
2957-21-3 - Physico-chemical Properties
| Molecular Formula | C16H14O5 |
| Molar Mass | 286.28 |
| Density | 1.370±0.06 g/cm3(Predicted) |
| Melting Point | 153-154°C |
| Boling Point | 555.9±50.0 °C(Predicted) |
| Specific Rotation(α) | D16 +8.0° (c = 7.92 in acetone); D12 +8.4° (c = 6.28 in methanol) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | neat |
| Color | White to Off-White |
| pKa | 7.42±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the Rosaceae cherry blossom Prunus serrulata. |
2957-21-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
2957-21-3 - Reference Information
| physical properties | the melting point is mp151 ~ 153 °c (methanol). Optical rotation [α]25D =-2.4 °(c0.5, methanol). The molecular formula C16H1405, the theoretical value is C,67.13%;H,4.90%; The measured value is C,67.00%;H,5.01%, the measured value is consistent with the theoretical value. 2.2.2UV,IRUV λmax (methanol):288,330nm. The IR(KBr) analysis results are shown in Table 1. 2)HRESI-MSm/z285.0764[M-H]-, consistent with the theoretical value (285.0763) of C16H13O5. 3) 1H-NMR, 1h-1hcy, 13CNMR,DEPT,HMQC,HMBC and other data were measured, which were consistent with the literature data. |
| Application | in vitro experiments have proved that the toxicity of the cherry blossom on the kidney cells (MDCK) is low, the median poisoning concentration (TC50) was 1709.9mg/L. (Cherry blossom) on canine kidney cell infection H5N1 Virus has obvious inhibitory effect, the half inhibitory concentration IC50 was 10.19, the therapeutic index TI (167.8), the TI of amantadine was significantly higher than that of positive control (11.02). The results showed that the in vitro effect of cherry blossom pigment on H5N1 Virus was significantly inhibited, and the toxicity was low. The results of the treatment of mice infected with H5N1 in vivo by the enzyme (cherry blossom kiosk) showed that the life rate of mice infected with H5N1 virus was prolonged, especially in the high and medium dose groups, the death protection rate was significantly higher than that of the control group; H5N1 virus infection can cause Viral Pneumonia of mice, Inflammatory exudation increases lung weight in mice, and the magnitude of the lung index value may indicate the severity of lung lesions. In the experiment, the lung index of mice can be reduced in different degrees in each dose group of cherry blossom (cherry blossom kiosk), and the experimental results of high and medium dose groups were significantly different from those of the control group. The results showed that each dose group had inhibitory effect on influenza virus Pneumonia in mice. The Pneumonia inhibitory rate of the mg/kg dose group was 98.05%, and the death protection rate was 86.00%, which was better than that of the positive control group; compared with the control group Virus, the death protection rate, life extension rate and average lung index of the mice were significantly different (P<0.05). The in vitro and in vivo experimental results showed that the effect of the inhibition of H5N1 Virus was significantly higher than that of the positive control amantadine, and the toxicity was lower than that of amantadine. |
| biological activity | Sakuranetin is a rice flavonoid phytoalexin with strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidant effects and can improve LPS-induced acute by lung injury. |
| Use | for content determination/identification/pharmacological experiments |
Last Update：2024-04-09 20:52:54
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Product Name: Sakuranetin Visit Supplier Webpage Request for quotationCAS: 2957-21-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Sakuranetin Visit Supplier Webpage Request for quotationCAS: 2957-21-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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