298-93-1
MTT
CAS: 298-93-1;2348-71-2
Molecular Formula: C18H16BrN5S
298-93-1 - Names and Identifiers
298-93-1 - Physico-chemical Properties
| Molecular Formula | C18H16BrN5S |
| Molar Mass | 414.32 |
| Density | 1.4886 (estimate) |
| Melting Point | 195 °C (dec.) (lit.) |
| Water Solubility | Slightly soluble.Clear yellow solution at 5mg in 1ml of water on vortexing |
| Solubility | Slightly soluble in methanol, but hardly soluble in water or ethanol. It cannot be completely dissolved with ether, acetone or ethyl acetate. |
| Appearance | Pale yellow or yellow powder or orange yellow powder |
| Color | Yellow to orange |
| Maximum wavelength(λmax) | ['378 nm, 242 nm'] |
| BRN | 3825277 |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Sensitive | Light Sensitive |
| MDL | MFCD00011964 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Thiazolyl Blue (MTT) is used in conjunction with rhodamine B to measure mitochondrial membrane potential. Thiazolyl Blue-formazan is generated in mitochondria acts as a fluorescence quencher for rhodamine that distributes across membranes of viable cells according to membrane potential. In the absence of mPMS, cellular reduction of Thiazolyl Blue is strong. Thiazolyl Blue is membrane-impermeable when incorporated into large unilamellar liposomes, and therefore it is taken up by cells via endocytosis. |
298-93-1 - Risk and Safety
| Risk Codes | R46 - May cause heritable genetic damage R68 - Possible risk of irreversible effects R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | XF8060000 |
| FLUKA BRAND F CODES | 3-8-10 |
| TSCA | Yes |
| HS Code | 29341000 |
298-93-1 - Introduction
It is commonly used to detect cell viability, cell proliferation or cytotoxicity based on MTT detection methods. Because MTT has a positive charge, it can pass through the cell membrane and be reduced by mitochondria to form a purple nail dye. Organic solvents are required to dissolve MTT methyl dye. Dehydrogenase detection, determination of enzyme activity in biochemical research, determination of NADH2, NADPH2 and myocardial yellow enzyme (Diaphorase).
Last Update：2022-10-16 17:24:22
298-93-1 - Reference Information
| biological field application | Cell viability say; microbial growth assays; DNA quantification assays; tissue viability assays; detecting enzymes; measuring membrane potential; treating Alzheimer's disease,asthma,cancer |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | Thiazolyl Blue (MTT, Tetrazolium bromide, Methylthiazolyldiphenyl-tetrazolium bromide, Methylthialazole Tetrazolium) is a cell permeable and positively charged colorimetric agent, It is widely used to detect reducing metabolism in cells and measure cell proliferation, cytotoxicity and apoptosis. Thiazolyl Blue (MTT) will be reduced from yellow to purple in living cells. |
| use | 1. determination of cytotoxicity of drugs (including other treatment methods such as radiation irradiation) on in vitro culture; 2. determination of cell proliferation and cell activity. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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