2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Names and Identifiers

Name	Vitamin E Acetate
Synonyms	Vitamin E Powder Vitamin E Acetate Tocopheryl acetate O-ACETYL-ALPHA-TOCOPHEROL 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanoacetate 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate 2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate (2R)-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate (2R)-2,5,7,8-tetramethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate (2S)-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate [2r-[2r(4r,8r*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-ol acetate
CAS	7695-91-2
EINECS	231-710-0
InChI	InChI=1/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23+,31+/m0/s1
InChIKey	ZAKOWWREFLAJOT-CEFNRUSXSA-N

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Physico-chemical Properties

Molecular Formula	C31H52O3
Molar Mass	472.74
Density	0.96 g/mL at 20 °C (lit.)
Melting Point	-28°C
Boling Point	224°C0.3mm Hg(lit.)
Flash Point	>230°F
Water Solubility	Immiscible with water.
Solubility	Soluble in chloroform, ether, acetone and vegetable oil, soluble in alcohol, insoluble in water
Vapor Presure	1.42E-09mmHg at 25°C
Vapor Density	16.3 (vs air)
Appearance	Transparent to yellow viscous oily
Specific Gravity	0.962 (20/4℃)
Color	Clear yellow viscous liquid
Odor	Odorless
Merck	14,9495
BRN	97512
Storage Condition	2-8°C
Sensitive	Air & Light Sensitive
Refractive Index	n20/D 1.497
MDL	MFCD00072052
Physical and Chemical Properties	Light yellow viscous liquid, relative density 0.957, freezing point -27.5 ℃, boiling point 200-250 ℃, refractive index 1.495-1.4972. Soluble in chloroform, ether, acetone and vegetable oil, soluble in alcohol, insoluble in water. Heat resistance is good, the light can be oxidized, color darkening. Mouse oral LD5010g/kg,ADL0.15-2 mg/kg(FAO/WHO,1994, product).
Use	Used as a medicine, nutrition, cosmetics additives

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	1
RTECS	GA8747000
FLUKA BRAND F CODES	8-10-23
TSCA	Yes
HS Code	29362800

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Reference Information

NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Main use	tocopherol acetate is the product of esterification of tocopherol (vitamin E) with acetic acid. Not estrogen, is a fat-soluble vitamin, with antioxidant properties, performance is more stable, for the yellowish or yellow transparent viscous liquid, almost odorless, light easily oxidized color gradient deep. Vitamin E contains a number of benefits, can promote the health of many aspects of the human body, it is widely used in a variety of personal care and hygiene products. Tocopherol acetate is not only a skin regulator, but also an antioxidant. When used in cosmetic ingredients, it has a protective effect such as preventing skin damage caused by sunlight ultraviolet rays. In addition, it can also be taken in the form of vitamin health products.
identification test	Take 30mg sample, add anhydrous ethanol 10ml, dissolve, add Nitric Acid 2ml, shake, heating at 75 °c for 15min, should be
content analysis	was determined by gas chromatography. Among them, the standard samples of the ester and vitamin E can be exclusively supplied by the drug and biological products Control Institute of the Ministry of Health of China.
toxicity	GRAS(FDA,§ 182.5892,§ 182.8892,2000).
usage limit	GB 14880 94: same as "01035, DL-α tocopherol".
uses	vitamin E prevents oxidation of cell membranes and intracellular unsaturated fatty acids and other easy oxides during the body's metabolism, so as to protect the integrity of the cell membrane and thus prevent the role of aging, can maintain the normal function of reproductive organs. Vitamin E has strong reducibility and can be used as an antioxidant. as an antioxidant in the body, it eliminates free radicals in the body and reduces the harm of ultraviolet rays to the human body. Because of skin care, hair care and other used as drugs, nutrition, cosmetics additives Vitamin E has a strong reducibility, in the human body metabolism in the process of antioxidant and prevent aging, can maintain the normal function of reproductive organs. General DL-vitamin E can be used as a nutrition enhancer, China's provisions can be used to strengthen sesame oil, salad oil, margarine and dairy products, the use of 100 ~ 180mg/kg; the dosage of fortified infant food was 40~70 μg/kg, and the maximum dosage of fortified tocopherol was 20~40mg/L; the amount used in the fortified milk beverage was 10-20 μg/kg. D-α-tocopherol, D-α-tocopherol acetate or DL-α-tocopherol may also be used for fortification, and the amount thereof must be converted. Natural Vitamin E concentrates can act as antioxidants.
production method	preparation and extraction of natural vitamin E with C1 ~ C4 lower alcohols or (5%~ 15%) c3 ~ C5 low ketone alcohol ketone mixture as extraction agent, extracted from vegetable oil. For example, 50ml of methanol is added to 100g of crude palm oil, the extraction is carried out at 45 ℃ by shaking, and the methanol phase is frozen overnight at -10 ~-20 ℃, the precipitated sterol and fatty acid crystals were removed by filtration, and the mother liquor was distilled to remove methanol to obtain a concentrated vitamin E content of 11%. In the esterification method, the deodorizer distillate in the oil and fat deodorization step is used as a raw material, the fatty acid therein is esterified with a polyhydric alcohol, and the ester is removed by steam distillation to obtain a concentrate. For example, 68.8g of soybean oil deodorizer distillate (acid value 133, saponification value 152, iodine value 1.1) is added with equivalent acid value of 41.4 times (240g) of glycerol, and xylene is used for reflux esterification (℃). Until the acid value is reduced to 0.5, the solvent is removed, and then the esterification product is distilled off with steam (under 400Pa). The free acid in the distillation process is esterified with glycerol, and finally the concentrate is obtained by distillation, the content was 56.3%, and the yield was 64.8%. Saponification method, enzymatic method and the like can also be used. Synthesis of DL-vitamin E 7.8g of 2,3, 5-trimethylhydroquinone, 6.8g of anhydrous zinc chloride and 1ml of glacial acetic acid were added to a mixed solvent of 20ml of dichloromethane and 5ml of diisopropyl ether, and stirred uniformly at room temperature; 95% g of isophytol was added dropwise within 3H, and the mixture was stirred for 30min after dropping. After completion of the reaction, the solvent was removed under reduced pressure, and the obtained reddish brown oil was dissolved in 15.6 of hexane, the product was washed with 2% NaOH solution and saturated brine successively, dried with mirabilite, and then the solvent was removed under reduced pressure to obtain 22.1g of crude tocopherol in the form of a red-orange oil, with a yield of 99% and a purity of 95%. The crude product was treated by Molecular distillation to give 18.9g of purified tocopherol in the form of a colorless oil with a yield of 88%. 25g of the above product was dissolved in 50ml of acetic anhydride, g of sodium acetate and 100g of sodium metal were added, and the mixture was stirred at 90-3.5 ° C. For hours. After acetylation, 200ml of hexane was added for extraction, and the extract was sequentially washed with 1% NaOH solution, water, and saturated brine. After dehydration with magnesium sulfate, hexane was removed to give 26.2g of crude vitamin E acetate. The crude product was subjected to vacuum distillation, and the fraction at 165-170 ° C. Was collected to obtain 20.5g of vitamin E acetate with a purity of 97.3% and a distillation yield of 78.0%. 1 preparation of natural vitamin E (1) extraction method. With C1-C4 low carbon alcohol or containing 5%-15% C3-C5 low carbon ketone alcohol ketone mixture as extraction agent, Extracted from vegetable oils. For example, 50ml of methanol is added to 100g of crude palm oil, the extraction is carried out at 45 °c by shaking, and the methanol phase is frozen overnight at -20-10 °c, the precipitated sterol and fatty acid crystals were removed by filtration, and the mother liquor was distilled to remove methanol to obtain a concentrated vitamin E solution with a content of 11%. (2) esterification method. The fatty acids in the deodorized distillate in the oil and fat deodorization step were esterified with polyhydric alcohols, and the esters were removed by steam distillation to obtain a concentrate. For example, 68.8g of soybean oil deodorizer distillate (acid value 133, saponification value 152, iodine value 1.1) is added with equivalent acid value of 41.4 times (240g) of glycerol, and the reflux esterification (C) is carried out with xylene. Until the acid value is reduced to 0.5, the solvent is removed and the ester is distilled off with steam (under 400pa). During the distillation, the free acid is esterified with glycerol, and finally the concentrate is obtained by distillation, with a content of 56.3%, the yield was 64.8%. Saponification method, enzymatic method and the like can also be used. Synthesis of 2dl-vitamin E 7.8 of g2,3, 5-trimethylhydroquinone, 6.8g of anhydrous zinc chloride and 1ml of glacial acetic acid were added to a mixed solvent of 20ml of dichloromethane and 5ml of diisopropyl ether, and stirred well at room temperature, 95% isophytol 15.6g was added dropwise within 3 hours, After dropping, the mixture was stirred for 30min. After completion of the reaction, the solvent was removed under reduced pressure, and the obtained red brown oily solid was dissolved in 150ml of hexane and washed with 2% NaOH solution and saturated brine successively, after drying with mirabilite, the solvent was removed under reduced pressure to obtain 22.1g of crude tocopherol in the form of a red-orange oil in a yield of 99% and a purity of 95%. The crude product was treated by Molecular distillation to give 18.9g of purified tocopherol in the form of a colorless oil in a yield of 88%. 25g of the above product were dissolved in 50ml of acetic anhydride, g of sodium acetate and 3.5g of sodium metal were added, and the mixture was stirred at 90-100 °c for hours. After acetylation, 200ml of hexane was added for extraction, and the extract was sequentially washed with 1% NaOH solution, water, and saturated brine. After dehydration with magnesium sulfate, hexane was removed to give 36.2G of crude vitamin E acetate. The crude product was subjected to vacuum distillation, and the fraction at 165-170 ° C. Was collected to obtain 20.5g of vitamin E acetate with a purity of 97.3% and a distillation yield of 78.0%.

Last Update：2024-04-09 21:00:56

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate

Jiangsu Pules Biotechnology Co.,Ltd.

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate

Vitamin E Acetate

CAS: 7695-91-2

Molecular Formula: C31H52O3

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Names and Identifiers

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Physico-chemical Properties

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Risk and Safety

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Reference Information

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2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate Request for Quotation

Vitamin E Acetate

CAS: 7695-91-2

Molecular Formula: C31H52O3

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Names and Identifiers

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Physico-chemical Properties

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Risk and Safety

2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate - Reference Information

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2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate