3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
CAS: 125-13-3
Molecular Formula: C20H15NO3
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE - Names and Identifiers
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE - Physico-chemical Properties
| Molecular Formula | C20H15NO3 |
| Molar Mass | 317.34 |
| Density | 1.352±0.06 g/cm3(Predicted) |
| Melting Point | 260-261 °C |
| Boling Point | 562.9±50.0 °C(Predicted) |
| pKa | 9.42±0.30(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Crystallization. Melting point> 260 ℃. |
| In vitro study | Oxyphenisatin has been shown to have antiproliferative activity. Oxyphenisatin acetate (OXY, NSC 59687) is the pro-drug of oxyphenisatin. OXY inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC 50 =0.8, 0.6, 2.1, 1.8 μM). This effect is associated with selective inhibition of translation accompanied by rapid phosphorylation of the nutrient sensing eIF2α kinases, GCN2 and PERK. |
| In vivo study | Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52. |
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.151 ml | 15.756 ml | 31.512 ml |
| 5 mM | 0.63 ml | 3.151 ml | 6.302 ml |
| 10 mM | 0.315 ml | 1.576 ml | 3.151 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE - Reference Information
| biological activity | Oxyphenisatin (Oxyphenisatin) is a laxative. Oxyphenisatin acetate is a prodrug of oxybifloxacin with anti-cancer activity. |
| Use | an intermediate of triacetaminophen. |
| production method | is prepared by condensation of indigo carmine with phenol in the presence of concentrated sulfuric acid. |
Last Update：2024-04-09 21:21:28
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Product Name: Oxyphenisatin Diacetate Impurity 1 (Oxyphenisatin) Visit Supplier Webpage Request for quotationCAS: 125-13-3
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Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE Visit Supplier Webpage Request for quotation
CAS: 125-13-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 125-13-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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