3,4,5-Trifluorobenzyl

3,4,5-Trifluorobenzyl - Names and Identifiers

Name	3,4,5-(trifluorophenyl)acetonitrile
Synonyms	3,4,5-Trifluorobenzyl 3,4,5-Trifluorobenzyl Cyanide 3,4,5-TRIFLUOROBENZYL CYANIDE Trifluorophenylacetonitrile 345- 3,4,5-TRIFLUOROPHENYLACETONITRILE 3,4,5-Trifluorophenyl acetonitrile 3,4,5-(trifluorophenyl)acetonitrile 2-(3,4,5-trifluorophenyl)acetonitrile Benzeneacetonitrile, 3,4,5-trifluoro-
CAS	220228-03-5
InChI	InChI=1/C8H4F3N/c9-6-3-5(1-2-12)4-7(10)8(6)11/h3-4H,1H2

3,4,5-Trifluorobenzyl - Physico-chemical Properties

Molecular Formula	C8H4F3N
Molar Mass	171.12
Density	1.334±0.06 g/cm3(Predicted)
Melting Point	30-32°C
Boling Point	214.1±35.0 °C(Predicted)
Flash Point	83.3°C
Vapor Presure	0.159mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.468
MDL	MFCD00083531

3,4,5-Trifluorobenzyl - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	3276
Hazard Note	Toxic
Hazard Class	6.1
Packing Group	III

3,4,5-Trifluorobenzyl - Introduction

3,4,5-(trifluorophenyl)acetonitril is an organic compound with the chemical formula C8H4F3N. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
1. Appearance: colorless liquid or solid.
2. Melting Point: about 30-32 ° C.
3. Boiling Point: about 135-136 ° C.
4. Density: About 1.37 g/cm.
5. Solubility: Soluble in some organic solvents, such as alcohols, ethers and chlorinated hydrocarbons.

Use:
1. 3,4,5-(trifluorophenyl)acetonitril can be used as a reagent or intermediate in organic synthesis.
2. It also has some applications in the field of medicine, such as for the preparation of drugs, pesticides and so on.

Method: A common preparation method of
3,4,5-(trifluorophenyl)acetonitril is as follows:
First, 3,4, 5-trifluorobenzaldehyde and sodium cyanide are added to the reaction bottle, and the reaction is carried out under alkaline conditions. After completion of the reaction, the intermediate product may be acidified with an acid etchant to obtain the target product.

Safety Information:
1. 3,4,5-(trifluorophenyl)acetonitril may be irritating and corrosive, and care should be taken when in contact with eyes, skin and respiratory tract.
2. In the process of operation, should wear appropriate protective gloves, protective glasses and protective clothing.
3. When exposed to the compound, rinse immediately with plenty of water and seek medical help if necessary.

Last Update：2024-04-09 21:01:54