3,4-DIHYDRO-1-(2H)NAPHTHALENEONE
Alpha-Tetralone
CAS: 529-34-0
Molecular Formula: C10H10O
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Names and Identifiers
| Name | Alpha-Tetralone |
| Synonyms | a-Tetralone A-TETRALONE 1-Tetralone α-Tetralone 1-TETRALONE Alpha-Tetralone ALPHA-TETRALONE KETOTETRAHYDRONAPHTHALENE 3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE 3,4-Dihydro-1(2H)-naphthalenone 3,4-DIHYDRO-1(2H)-NAPHTHALENONE 3,4-DIHYDRO-1-(2H)NAPHTHALENEONE 1,2,3,4-Tetrahydro-1-naphthalenone 1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE |
| CAS | 529-34-0 |
| EINECS | 208-460-6 |
| InChI | InChI=1/C10H10O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6H,3,5,7H2 |
| InChIKey | XHLHPRDBBAGVEG-UHFFFAOYSA-N |
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Physico-chemical Properties
| Molecular Formula | C10H10O |
| Molar Mass | 146.19 |
| Density | 1.099g/mLat 25°C(lit.) |
| Melting Point | 2-7°C(lit.) |
| Boling Point | 113-116°C6mm Hg(lit.) |
| Specific Rotation(α) | n20/D 1.568 (lit.) |
| Flash Point | >230°F |
| Water Solubility | insoluble |
| Solubility | Insoluble in water, soluble in ethanol, ether and other solvents. |
| Appearance | Colorless oily liquid |
| Color | brown |
| BRN | 607374 |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to air |
| Refractive Index | n20/D 1.568(lit.) |
| MDL | MFCD00001688 |
| Physical and Chemical Properties | Colorless oily liquid, slightly yellowish for industrial use. Light color gradually darkened to dark red, slightly similar to camphor odor, when heated with mint odor. Melting point 8 ℃, boiling point 255-257 ℃,129.4 ℃(1.6kPa), relative density (15.6 ℃)1.098, refractive index 1.5712(15.45 ℃),1.5693(20 ℃). Insoluble in water, soluble in a variety of organic solvents. |
| Use | Used as a variety of drugs such as contraceptives, rodenticides and other intermediates, also used as solvents and plastic softeners. |
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R20/22 - Harmful by inhalation and if swallowed. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | QK4375000 |
| TSCA | Yes |
| HS Code | 29143900 |
| Toxicity | LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg |
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Nature
Open Data Verified Data
colorless oily liquid, with slightly light yellow in industrial products, gradually darkened to dark red in light, slightly similar to camphor, with mint odor when heated. Insoluble in water, soluble in a variety of organic solvents. Melting point 8 °c. Boiling point 255~257 deg C. The relative density of 1.098 (15.6 deg C). Refractive index 1. 5712 (15. 45 °c),1.5693(20 °c).
Last Update：2024-01-02 23:10:35
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Preparation Method
Open Data Verified Data
- tetrahydronaphthalene oxidation method can oxidize tetrahydronaphthalene with chromic anhydride and hydrogen peroxide; Oxygen or air can also be used in the presence of cobalt, copper, manganese, nickel and other metal salt catalysts or alkyl pyridine and chromium salt composite catalysts, the oxidation of tetrahydronaphthalene was obtained.
- y phenylbutyric acid cyclization method by y phenylbutyric acid and phosphoric acid phosphoric acid phosphoric acid anhydride, Polyphosphoric acid, hydrofluoric acid or concentrated sulfuric acid, and then by the cyclization of the system. The reaction temperature was 90 ° C. And the yield was 75%-86%.
- y benzoyl chloride cyclization in the presence of anhydrous aluminum chloride or anhydrous tin tetrachloride dehydrochlorination cyclization of this product.
- y butyrolactone method by condensation with benzene to this product, requires the use of thiophene-free benzene, the yield can reach 91% ~ 96%.
Last Update：2022-01-01 10:42:50
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Introduction
The color of the light gradually darkens to dark red, slightly similar to camphor smell, and mint smell when heated. Insoluble in water, soluble in various organic solvents.
Last Update：2022-10-16 17:25:55
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Use
Open Data Verified Data
It is mainly used for the dehydrogenation of naphthol; The pharmaceutical industry is used for the synthesis of 18-methyl. It can also be used as a solvent and plastic softening agent, and its chloride has insecticidal and repellent effects.
Last Update：2022-01-01 10:42:50
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Safety
Open Data Verified Data
- ingestion is harmful, skin contact and inhalation are irritating. Should wear protective glasses, protective clothing, protective gloves. Its gas forms an explosive mixture with air. Combustion produces irritant, corrosive and (or) toxic gases.
- 200kg iron drum. Store in a cool and dry place, the container is highly sealed. Keep away from strong oxidants and strong reducing agents.
Last Update：2022-01-01 10:42:51
3,4-DIHYDRO-1-(2H)NAPHTHALENEONE - Reference Information
| update date: | 2022/11/12 10:05:38 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | white crystalline powder at low temperature. Odorless, sour, soluble in water and ethanol, insoluble in chloroform. Density 1.096, melting point 5-6°C, boiling point 127 C (13 mmHg), refractive index 1.5675-1.5695, flash point 130°C, water solubility insoluble. Used in the synthesis and preparation of a variety of chiral food additives and nutritional additives. Such as the resolution process of new functional nutritional additive L-carnitine and some chiral drugs. Also used in beverages, candy, bread, gelatin as sour agent, biochemical reagent, racemate splitting agent, pharmaceutical splitting agent. It is also used in photography, canned food manufacturing, printing and dyeing, ceramic making, and the preparation of other splitting agents and salts, esters, pharmaceutical intermediates, etc. It is also an intermediate of a variety of drugs (contraceptives, rodenticides), and is also used as a solvent and plastic softener. |
| Synthesis and catalysis of chiral tetralin amine derivatives | Using 1-tetrahydronaphthone and ammonium formate as starting materials, the amination and hydrolysis (±)-1-tetralin amine was synthesized. Then L-( )-tartaric acid is used as the resolution reagent, and 90% ethanol is used for step-by-step crystallization to obtain optically pure (R)-1-tetrahydronaphthalene amine. |
| Use | Mainly used for dehydrogenation to prepare naphthol. An intermediate of the contraceptive 18-methylnorethisterone. Also used as solvent and plastic softener. Intermediate of pesticide rodenticide. Its chloride has insecticidal and avoidance effects. It is used as an intermediate for a variety of drugs such as contraceptives, rodenticides and other intermediates, as well as as solvents and plastic softeners. 1-Tetrahydronaphthone (benzobutyric acid USP-related compound B) is a kind of synthesis with anti-NF-κB and pro-apoptotic potential Aminopyrazopyridine reagent. It is mainly used in dehydrogenation to prepare naphthol; the pharmaceutical industry is used to synthesize 18-methylnorethindrone (contraceptive) and rodenticide intermediates, and it is also an important intermediate for the synthesis of benazepril. In addition, it can also be used as a softener for solvents and plastics, and its chloride has insecticidal effects. |
| production method | there are many process routes. 1. There are many catalysts and oxidants that can be selected for the tetrahydronaphthalene oxidation method. The method suitable for large-scale industrial production is to use chromium acetate and 2-methyl-5-ethylpyridine composite catalyst, using air as the oxidant, Carry out atmospheric continuous liquid phase oxidation, the reaction temperature is 130 ℃, the molar ratio of tetrahydronaphthalene to oxygen is 1:0.6, the residence time is 60-70min, the one-way conversion rate of tetrahydronaphthalene can reach more than 20%, the selectivity of 1-tetrahydronaphthone is about 90%, and the main by-product is tetrahydronaphthol. The product is fractionated under reduced pressure to obtain 98% tetrahydronaphthone. 2.γ-butyrolactone is obtained by condensation with benzene. Thiophene-free benzene should be used as raw material, and the yield can reach 91%-96%. 3.γ-phenylbutyric acid cyclization method γ-phenylbutyric acid was cyclized at 90 ℃ under the action of phosphoric acid/phosphate anhydride, polyphosphoric acid, hydrofluoric acid or concentrated sulfuric acid to obtain 1-tetrahydronaphthone with a yield of 75-86%. 4.γ-phenylbutyryl chloride cyclization method dehydrochlorination in the presence of anhydrous aluminum trichloride or anhydrous tin tetrachloride to obtain this product. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:09
Supplier List
Spot supply
Product Name: Alpha-Tetralone Request for quotationCAS: 529-34-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Alpha-Tetralone Request for quotationCAS: 529-34-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: Alpha-Tetralone Request for quotationCAS: 529-34-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: 1-Tetralone Request for quotation
CAS: 529-34-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
CAS: 529-34-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: Alpha-Tetralone Request for quotation
CAS: 529-34-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 529-34-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: α-Tetralone Visit Supplier Webpage Request for quotationCAS: 529-34-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Alpha-Tetralone Request for quotationCAS: 529-34-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Alpha-Tetralone Request for quotationCAS: 529-34-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: Alpha-Tetralone Request for quotationCAS: 529-34-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: 1-Tetralone Request for quotation
CAS: 529-34-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
CAS: 529-34-0
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: Alpha-Tetralone Request for quotation
CAS: 529-34-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 529-34-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: α-Tetralone Visit Supplier Webpage Request for quotationCAS: 529-34-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History