3,4-DIHYDROXYPHENETHYLAMINE,HCL
DOPAMINE HYDROCHLORIDE
CAS: 335081-04-4
Molecular Formula: C8H12ClNO2
3,4-DIHYDROXYPHENETHYLAMINE,HCL - Names and Identifiers
3,4-DIHYDROXYPHENETHYLAMINE,HCL - Physico-chemical Properties
| Molecular Formula | C8H12ClNO2 |
| Molar Mass | 189.64 |
| Melting Point | 248-250°C(lit.) |
| Solubility | alcohol: 20mg/mL |
| Color | light tan |
| Storage Condition | 0-6°C |
3,4-DIHYDROXYPHENETHYLAMINE,HCL - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | UX1092000 |
| FLUKA BRAND F CODES | 8-10-23 |
3,4-DIHYDROXYPHENETHYLAMINE,HCL - Determination of dopamine hydrochloride by flow injection chemiluminescence
from VIP Journal Professional Edition
Author:
du Lingyun , Wang Zhuhao , Lin Shi Lei
Abstract:
A new flow injection chemiluminescence method for the determination of dopamine hydrochloride was established based on the synergistic effect of dopamine hydrochloride and tannin on the oxidation of luminol by KIO4 in alkaline medium. The linear range of dopamine hydrochloride was 2.0 × 10 ^-10~6.0 × 10 ^-8g/mL, and the detection limit was 1.17 × 10 ^-10g/mL, the relative standard deviation for 11 determinations of 8.0 × 10 ^-10g/mL dopamine hydrochloride is 1.92%. The method can be applied to the determination of dopamine hydrochloride in dopamine hydrochloride injection and urine.
Key words:
flow injection chemiluminescence dopamine hydrochloride luminol
DOI:
10.3969/j.issn.1000-0720.2005.07.026
cited:
year:
2005
Last Update：2024-01-02 23:10:35
3,4-DIHYDROXYPHENETHYLAMINE,HCL - Determination of dopamine hydrochloride injection by HPLC
from hownet
Author:
Abstract:
Objective to establish an HPLC method for the determination of dopamine hydrochloride in dopamine hydrochloride injection. Methods the samples were determined by external standard method and dissolved in water. Analysis was performed on a hypersilb dsc18 column (5 μm,4.6mm × 150mm) with the mobile phase of phosphate buffer (pH5.8) Methanol (98:2) at a flow rate of 1.0ml/min and the detection wavelength at 280nm. Results there was a good linear relationship between dopamine hydrochloride concentration and peak area ratio in the range of 20~120 μg/ml (r = 0.99995), the precision was 0.70%, and the stability test RSD was 0.29%, the sample recovery rate was 99.7%. The content of dopamine hydrochloride determined by HPLC has no significant difference compared with spectrophotometry, but the result is more close to the theoretical value. Conclusion The method is simple, accurate, reliable and reproducible, and the RSD is less than 1.0%. It can be used for the determination of dopamine hydrochloride in dopamine hydrochloride injection.Key words:
HPLC dopamine hydrochloride injection Content determination UV
DOI:
10.3969/j.issn.1674-229X.2005.03.009
cited:
year:
2005
Last Update：2023-08-16 22:09:08
3,4-DIHYDROXYPHENETHYLAMINE,HCL - Production method of dopamine hydrochloride injection
from Google Patents
Public/Announcement Number:
CN101953782 A
Public/announcement date:
Jan 26, 2011
inventor:
Wu Haoping , Sun Kegang , Shi Jianguo
Abstract:
The invention relates to a production method of dopamine hydrochloride injection, which is realized by the following steps: taking 50%-80% of the prepared water for injection, passing through CO215 for 30 minutes to make it saturated; take the weight volume ratio of 1% dopamine hydrochloride and 0.15% ~ 0.25% sodium bisulfite into the above saturated water with CO2, stir and dissolve; Adjust the pH value of the injection with sodium hydroxide or hydrochloric acid to 3.2~4.3, add water for injection to the whole amount and stir evenly; Filter, potting, sterilization under the condition of 115~121 ℃ for 12~30 minutes; The beneficial effects of the invention are: good product stability, exact curative effect, not easy to decompose, precipitation, high level of sterility assurance (F0 ≥ 12), can realize large-scale industrial production.
Last Update：2023-08-16 22:09:08
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