3,4-Dimethoxyaniline
4-Aminoveratrole
CAS: 6315-89-5
Molecular Formula: C8H11NO2
3,4-Dimethoxyaniline - Names and Identifiers
| Name | 4-Aminoveratrole |
| Synonyms | 4-AMINOVERATROL 4-aminoveratrol 4-Aminoveratrole 4-AMINOVERATROLE 3,4-Dimethoxyaniline 3,4-dimethoxy-anilin Aniline, 3,4-dimethoxy- 3,4-dimethoxy-benzenamin 3,4-dimethoxybenzenamine 2-Methoxy-4-aminoanisole 3,4-Dimethoxyaniline(4-Aminoveratrole) |
| CAS | 6315-89-5 |
| EINECS | 228-647-6 |
| InChI | InChI=1/C8H11NO2/c1-10-7-4-3-6(9)5-8(7)11-2/h3-5H,9H2,1-2H3 |
3,4-Dimethoxyaniline - Physico-chemical Properties
| Molecular Formula | C8H11NO2 |
| Molar Mass | 153.18 |
| Density | 1.1577 (rough estimate) |
| Melting Point | 85-89 °C (lit.) |
| Boling Point | 174-176 °C/22 mmHg (lit.) |
| Flash Point | 174-176°C/22mm |
| Water Solubility | insoluble |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Vapor Presure | 0.00145mmHg at 25°C |
| Appearance | Ash powder |
| Color | Brown |
| BRN | 743399 |
| pKa | 4.78±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.4640 (estimate) |
| MDL | MFCD00008394 |
| Physical and Chemical Properties | Light brown crystal, melting point 86-88 ℃. |
| Use | Used as a pharmaceutical Intermediate |
3,4-Dimethoxyaniline - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | BX4550000 |
| TSCA | Yes |
| HS Code | 29222900 |
| Hazard Note | Toxic/Irritant |
| Hazard Class | 6.1(b) |
| Packing Group | III |
3,4-Dimethoxyaniline - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | 3, 4-dimethoxyaniline is a chemical substance with the molecular formula c8h11no2. Light red or light yellow powder that turns light brown when exposed to air. Soluble in dilute inorganic acid, ethanol and ether, water-soluble. At present, the production of 3,4-dimethoxy aniline method has 3, 4-dimethoxy nitrobenzene iron powder reduction, sodium sulfide reduction method, hydrogenation reduction method, special powder reduction and sodium sulfide reduction, there are three waste, serious environmental pollution and can not be continuous production, low production capacity. |
| Application | 3, 4-dimethoxyaniline is an important fine chemical intermediate, mainly used in pharmaceutical and dye industry, it can be used for the preparation of intermediates of ice dye black salt K and intermediates of medicine, insecticide and antioxidant. |
| preparation | (1) put 5000kg of methanol and 1250kg of 3, 4-dimethoxynitrobenzene into a chemical reactor, the subsequent feeding is carried out according to the ratio, stirred evenly, pumped into the first-stage hydrogenation reactor, and 125kg of Pd/Al2O3 catalyst is added. The particle size of the catalyst is 10nm, and the nitrogen replacement system is introduced for three times, then the hydrogen replacement system is introduced three times, the stirring is started, the temperature is raised to 90-100 ℃, and the raw material liquid of 3, 4-dimethoxynitrobenzene is pumped into the first-stage hydrogenation kettle at a flow rate of 6000L/h, and H2 is introduced, the hydrogen pressure in the control system is 1.0MPa, and 2.5 of Pd/Al2O3 catalyst is added to the first-stage hydrogenation reactor at 3H intervals. After the materials in the first-stage hydrogenation reactor are gradually increased, flow into the second-stage hydrogenation kettle through the overflow port, and the residence time of the material in the hydrogenation kettle is about 2-3H. After the reaction is qualified (the residual amount of 3, 4-dimethoxynitrobenzene is less than or equal to 0.2%), after the Second Stage Hydrogenation kettle overflow to the settling kettle. (2) the feed liquid is settled in the sedimentation kettle, the lower catalyst is pumped into the hydrogenation kettle, the upper reduction liquid is pumped into the membrane filtration system by the pump, and the two membrane filters are connected in series, the internal circulation is realized by a pump, the catalyst in the reduction solution is gradually concentrated to 10-30%, and the concentrated catalyst feed liquid is driven into the catalyst feeding tank by the pump to realize internal circulation. The membrane used in this step was a ceramic membrane with an average pore size of 2nm. (3) the filtered reducing liquid enters the distillation kettle, and after the temperature is raised to remove the solvent methanol, the liquid is put into the crystallization kettle and purified to obtain 3, 4-dimethoxyaniline product with a content of 99.9%, capacity 950kg/h. |
| Use | intermediate of medicine and dye. for pharmaceutical intermediates |
Last Update：2024-04-09 15:16:52
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