3,4-dihydroxy-2-(methylamino)acetophenone
adrenalone
CAS: 99-45-6
Molecular Formula: C9H11NO3
3,4-dihydroxy-2-(methylamino)acetophenone - Names and Identifiers
| Name | adrenalone |
| Synonyms | adrenalone ADRENALONE AKOS NCG-0050 4-methylaminoacetocatechol 4-(methylaminoacetyl)catechol 4-methylaminoacetopyrocatechol 3,4-dihydroxy-2-(methylamino)acetophenone 3,4-dihydroxy-alpha-methylaminoacetophenone 3',4'-dihydroxy-2-(methylamino)-acetophenon 3',4'-dihydroxy-2-(methylamino)acetophenone 1-(3,4-dihydroxyphenyl)-2-(methylamino)-ethanon |
| CAS | 99-45-6 |
| EINECS | 202-756-9 |
| InChI | InChI=1/C9H11NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,10-12H,5H2,1H3 |
3,4-dihydroxy-2-(methylamino)acetophenone - Physico-chemical Properties
| Molecular Formula | C9H11NO3 |
| Molar Mass | 181.19 |
| Density | 1.2375 (rough estimate) |
| Melting Point | 235.5°C (rough estimate) |
| Boling Point | 314.29°C (rough estimate) |
| Solubility | Soluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble |
| Appearance | Solid |
| Color | Pale Yellow to Light Yellow |
| pKa | 7.32±0.20(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.5270 (estimate) |
| MDL | MFCD00037715 |
| Physical and Chemical Properties | Needle-like crystals. Decomposition temperature 235-236 ℃, slightly soluble in water, alcohol, ether. Its hydrochloride, melting point 243 ℃, soluble in water, soluble in ethanol, insoluble in ether. |
3,4-dihydroxy-2-(methylamino)acetophenone - Reference
| Reference Show more | 1. Wang Shuai, Guo Qiusheng, Shi Hongzhu, etc. Effects of short-term addition of 17 β-e2 on growth and gonadal development of winter Leech. 2. [IF = 5.037] Tao Wu et al."Chronicucocorticoid treatment induced (CDI)." Life Sci. 2018 Jan;192:173 3. [IF = 2.877] Tao Wu et al."Timing of glucocorticoid administration determines severity of lipid metabolism and behavioral effects in rats."Chronobiol Int. 2017;34(1):78-92 4. [IF=7.711] Rong Zhang et al."A Disposable Printed Liquid Gate Graphene Field Effect Transistor for a Salivary Cortisol Test."Acs Sensors. 2021;6(8):3024-3031 |
3,4-dihydroxy-2-(methylamino)acetophenone - Reference Information
| Introduction | corticosterone is used as a local vasoconstrictor and a hemostatic adrenergic agonist. Previously, it was also used to prolong the effects of local anesthetics. It is the Ketone form of epinephrine. |
| Use | intermediate of hemostatics, anluoxue and non-steroidal hormone drugs. |
| production method | the production of chloroacetylcatechol from catechol, chloroacetic acid, and phosphorus oxychloride via a Freund-gram reaction, further, the amination reaction with methylamine was carried out to obtain corticosterone. |
Last Update：2024-04-09 20:45:29
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