Name | clopidol |
Synonyms | clopidol Clopindol coccidiostatc Clopidol -Total dust ClopidolMeticlopidol Clopidol, respirable dust 3,5-Dichloro-2,6-Dimethylpyridinol 3,5-dichloro-2,6-dimethyl-4-pyridino 4-Pyridinol, 3,5-dichloro-2,6-dimethyl- 3,5-dichloro-2,6-dimethylpyridin-4(1H)-one 3,5-dichloro-2,6-dimethylpyridin-4(3H)-one |
CAS | 2971-90-6 |
EINECS | 221-008-2 |
InChI | InChI=1/C7H7Cl2NO/c1-3-5(8)7(11)6(9)4(2)10-3/h5H,1-2H3 |
InChIKey | QCMHHYSPKNVXLR-UHFFFAOYSA-N |
Molecular Formula | C7H7Cl2NO |
Molar Mass | 192.04 |
Density | 1.2494 (rough estimate) |
Melting Point | >320℃ |
Boling Point | 318.4±37.0 °C(Predicted) |
Flash Point | 70.4°C |
Water Solubility | 40mg/L(temperature not stated) |
Solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated) |
Vapor Presure | 0.117mmHg at 25°C |
Appearance | White to light brown, crystalline solid |
Color | White to Off-White |
pKa | 5.50±0.33(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Stability | Hygroscopic |
Refractive Index | 1.5500 (estimate) |
MDL | MFCD00867211 |
Physical and Chemical Properties | White or pale yellow powder. Odorless. |
Use | It is one of the most widely used Anticoccidial drugs in China, which is effective for all kinds of chicken coccidia, and is usually mixed with animal feed for continuous administration. |
In vitro study | Clopidol is a veterinary drug additive widely used to prevent coccidia infection in chickens. Clopidol is banned for poultry for export, and the maximum residue level (MRL) of Clopidol in chicken is set at 0.01 mg/kg in the People's Republic of China (P. R. China). Clopidol inhibits electron transport in mitochondria isolated from unsporulated oocysts. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 2 |
RTECS | UU7711500 |
HS Code | 29333990 |
Toxicity | LD50 orally in rats: 18 g/kg (Plisek) |
Raw Materials | Dehydroacetic acid |
white or light brown crystals, odorless and tasteless. Insoluble in most organic solvents and water, slightly soluble in strong alkali or acid solution. With metal oxides to form metal salts, the performance is very stable
The coccidiostat has a broad spectrum of insect resistance, and has a good effect on chicken's tenderness, toxicity, Brinell, giant, pile-type, and mitigation of precocious Eimeria. On Turkey coccidiosis, according to the same concentration of broiler feed, also has excellent preventive effect. Can be used for avian and rabbit coccidiosis.
rat oral LD50: 18g/kg.
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
precautions | 1. broilers cannot stop taking medicine halfway during the whole brooding period because this product inhibits the immunity of chickens to coccidia. Laying hens and breeding broilers are not suitable for use. Since this product is more likely to produce drug-resistant insect species or insect strains, other anticoccidial drugs must be used in rotation as planned. The combined application of chloropyridine and benzoxyquinyl has a certain synergistic effect. 2. Drug withdrawal period: 5 days for chickens and 5 days for rabbits. |
use | has good effects on 9 species of Eimeria in chickens, especially on Eimeria tenella. The peak period of its activity is the sporozoite stage (that is, the first day of infection), so it can be administered before infection or at the same time as infection. It is more suitable for preventive drugs or early treatment drugs. There are data that prove that chloropyridine can inhibit the immunity of chickens to coccidia, and the drug is stopped too early, which often leads to the outbreak of coccidiosis. It is currently believed that coccidia are prone to drug resistance to this product. This product also has a certain control effect on rabbit coccidia. It is one of the most widely used anticoccidial drugs in China. It is effective against all kinds of chicken coccidia. It is usually mixed in animal feed and used continuously. Hydroxypyridine anticoccidial drugs. |
biological activity | Clopidol (WR 61112) is an antigenic insect agent. |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |