3,5-dichloro-4-bromofluorobenzene
5-bromo-1,3-dichloro-2-fluorobenzene
CAS: 17318-08-0
Molecular Formula: C6H2BrCl2F
3,5-dichloro-4-bromofluorobenzene - Names and Identifiers
3,5-dichloro-4-bromofluorobenzene - Physico-chemical Properties
| Molecular Formula | C6H2BrCl2F |
| Molar Mass | 243.89 |
| Density | 1.823 |
| Boling Point | 234℃ |
| Flash Point | 96℃ |
| Vapor Presure | 23.8-112Pa at 30-50℃ |
| Appearance | Liquid |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.567 |
3,5-dichloro-4-bromofluorobenzene - Reference Information
| LogP | 4.4 at 20℃ and pH7 |
| Use | 3, 5-dichloro-4-fluorobromobenzene is an intermediate in organic synthesis, can be used in the laboratory of organic synthesis and pharmaceutical research and development process. |
| preparation | (1) the ammonium salt and the aqueous solution of sodium nitrite are simultaneously fed into a tubular reactor for performing a tubular diazotization reaction to obtain a diazonium salt Intermediate; the ammonium salt is prepared by dissolving 3, 5-dichloro-4-fluoroaniline in sulfuric acid;(2) dissolving cuprous bromide in hydrobromic acid and warming up to 100-130 °c, the diazonium salt intermediate obtained in the step (1) was added dropwise for reaction, and after the reaction was completed, the 3, 5-dichloro-4-fluorobromobenzene was obtained by post-treatment. |
Last Update：2024-04-09 21:11:58
