3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine

3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine - Names and Identifiers

Name	3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine
Synonyms	MPEG8-NH2 m-PEG8-amine m-dPEG8-Amine m-dPEG??-amine m-dPEG(R)8-amine 3,6,9,12,15,18,21,24- 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
CAS	869718-81-0

3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine - Physico-chemical Properties

Molecular Formula	C17H37NO8
Molar Mass	383.48
Density	1.054
Boling Point	448.0±40.0 °C(Predicted)
Appearance	Morphological solid or viscous liquid
pKa	8.74±0.10(Predicted)
Storage Condition	-20°C
Physical and Chemical Properties	Bioactive m-PEG8-Amine is a degradable (cleavable) ADC linker used in the synthesis of antibody-coupled drugs (ADCs).
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine - Upstream Downstream Industry

Raw Materials

m-PEG9-Tos
MPEG8-N3
OCTAETHYLENE GLYCOL MONOMETHYL ETHER

3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine - Uses and synthesis methods

target

CleavablePEGs

in vitro study

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-10 22:29:15

3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine - Reference Information

biological activity	m-PEG8-Amine is a degradable (cleavable) ADC linker used for antibody-coupled drugs (ADCs) synthesis.
target	Cleavable PEGs
in vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-09 20:49:11