3,6,9,12,15,18-Hexaoxanonadecan-1-amine

3,6,9,12,15,18-Hexaoxanonadecan-1-amine - Names and Identifiers

Name	2,5,8,11,14,17-Hexaoxanonadecan-19-amine
Synonyms	MPEG6-NH2 m-PEG6-amine Methyl-PEG6-amine 3,6,9,12,15,18-Hexaoxanonadecan-1-amine 2,5,8,11,14,17-Hexaoxanonadecan-19-amine 2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanamine 1-amino-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane
CAS	184357-46-8

3,6,9,12,15,18-Hexaoxanonadecan-1-amine - Physico-chemical Properties

Molecular Formula	C13H29NO6
Molar Mass	295.37
Density	1.036
Boling Point	368.5±37.0 °C(Predicted)
pKa	8.74±0.10(Predicted)
Storage Condition	-20°C
Physical and Chemical Properties	Bioactive m-PEG6-Amine is a PROTAC connection bridge and belongs to PEG class. m-PEG6-Amine can be used to synthesize a series of PROTAC molecules. m-PEG6-Amine is a degradable (cleavable) ADC link bridge for the synthesis of antibody drug conjugates (ADCs).

3,6,9,12,15,18-Hexaoxanonadecan-1-amine - Upstream Downstream Industry

Raw Materials

Hexaethylene glycol
2,5,8,11,14,17-Hexaoxanonadecan-19-ol, methanesulfonate
MPEG6-N3
2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate
HEXAETHYLENE GLYCOL MONOMETHYL ETHER
m-PEG7-Tos
TRIETHYLENE GLYCOL MONOMETHYL ETHER
Ammonium hydroxide

3,6,9,12,15,18-Hexaoxanonadecan-1-amine - Uses and synthesis methods

target

CleavablePEGs

in vitro study

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Last Update：2024-04-10 22:29:15