3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one
droperidol
CAS: 548-73-2
Molecular Formula: C22H22FN3O2
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Names and Identifiers
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Physico-chemical Properties
| Molecular Formula | C22H22FN3O2 |
| Molar Mass | 379.43 |
| Density | 1.2154 (estimate) |
| Melting Point | 148-149°C |
| Water Solubility | 4.1mg/L(30 ºC) |
| Solubility | Practically insoluble in water, freely soluble in dimethylformamide and in methylene chloride, sparingly soluble in ethanol (96 per cent). |
| Appearance | neat |
| Color | Pale Yellow to Pale Beige |
| pKa | 7.64(at 25℃) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.613 |
| Use | Used as an antipsychotic |
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | DE2100000 |
| HS Code | 2933995800 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 750mg/kg |
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Standard
Authoritative Data Verified Data
This product is 1-[1_[3-(4-chlorophenylmethyl) propyl]-1,2 ,3, 6-tetrachloro-4-pyridyl]-2-benzimidazolinone. Calculated as dried product, the content of C22H22FN302 shall not be less than 98.0%.
Last Update：2024-01-02 23:10:35
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Trait
Authoritative Data Verified Data
- This product is white to light yellow crystalline powder; Odorless; Easy to change color when exposed to light.
- This product is soluble in chloroform or N,JV-dimethylformamide, very slightly soluble in ethanol or ethyl acetate, insoluble in water.
Last Update：2022-01-01 13:40:47
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.636 ml | 13.178 ml | 26.355 ml |
| 5 mM | 0.527 ml | 2.636 ml | 5.271 ml |
| 10 mM | 0.264 ml | 1.318 ml | 2.636 ml |
| 5 mM | 0.053 ml | 0.264 ml | 0.527 ml |
Last Update：2024-01-02 23:10:35
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Differential diagnosis
Authoritative Data Verified Data
- take this product, add hydrochloric acid solution (9-1000) dissolved and diluted to make solution containing 15ug per lml, according to UV-visible spectrophotometry (General 0401) determination, at 228nm, there is a maximum absorption at the wavelength of 246nm and 276nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1171).
Last Update：2022-01-01 13:40:47
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Exam
Authoritative Data Verified Data
Related substances
use new system, use brown measuring bottle. Take this product, add 1% lactic acid solution to dissolve and dilute to make a solution containing about 1 mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, as a control solution, it was diluted to scale with 1% lactic acid solution and shaken. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with eighteen alkyl silane is used as the filler (BDS or equivalent column is applicable); 0.34% tetrabutylammonium hydrogen sulfate solution is used as the mobile phase A, gradient elution was carried out using ethyl-as mobile phase B at a flow rate of 1.5ml per minute and a detection wavelength of 275nm. Take 5mg of Droperidol and 5mg of domperidone in a 100ml measuring flask, add 1% lactic acid solution to dissolve and dilute to scale, shake well, inject 20ul into liquid chromatograph, record chromatogram, the resolution between droperidol peak and domperidone peak should be greater than 3.5.
precision
20ul of the control solution and the test solution were injected into the human liquid chromatograph respectively, and the chromatograms were recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0%), the sum of each impurity peak area shall not be greater than 2 times (2.0%) of the main peak area of the control solution. The chromatogram of the test solution is 0.05 times smaller than the main peak area of the control solution.
loss on drying
take this product, at 70°C under reduced pressure drying to constant weight, weight loss should not exceed 5.0% (General rule 0831).
ignition residue
take this product 1.Og, put it in a platinum crucible, and check it according to law (General rule 0841). The residue left shall not exceed 0.2%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 13:40:48
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Content determination
Authoritative Data Verified Data
take the dried product of about 0.3g, precision weighing, add glacial acetic acid 30ml, slightly warm to dissolve, add 2 drops of naphthol benzyl alcohol indicator solution, with high chlorine cut titration solution (0.1 mol/L) titration to the solution is green, and the result of the titration is corrected with a blank test. Per 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 37.94mg of C22H22FN302.
Last Update：2022-01-01 13:40:49
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Category
Authoritative Data Verified Data
antipsychotics.
Last Update：2022-01-01 13:40:49
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:40:49
3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one - Droperidol Injection
Authoritative Data Verified Data
droperidol (C22H22FN303) should be 90.0% to 110.0% of the labeled amount.
trait
This product is colorless to yellowish clear liquid.
identification
- take this product and dilute with water to make a solution containing 15ug droperidol per lml, and measure by UV-Vis spectrophotometry (General rule 0401) at 228nm, there is a maximum absorption at the wavelength of 246nm and 276nm.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- the pH value should be 3.5 to 5.0 (General 0631).
- Related substances are newly prepared for use, using brown measuring flask. Take this product and dilute with 1% lactic acid solution to make a solution containing droperidol 1 mg per 1ml as a test solution; Take 1ml and put it in a 100ml measuring flask for precision measurement, add 1% lactic acid solution diluted to the scale, shake, as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the control solution and the test solution are respectively injected into the liquid chromatograph, and the chromatograms are recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be 2 times (2.0%) the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 3 times (3.0%) of the main peak area of the control solution. The chromatogram of the test solution is 0.05 times smaller than the main peak area of the control solution.
- bacterial endotoxin take this product, according to the law inspection (General 1143), the amount of endotoxin per 1 mg droperidol should be less than 15EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test with eighteen alkyl silane bonded silica gel as filler (BDS or efficacy equivalent column is applicable); 0.34% tetrabutylammonium hydrogen sulfate solution as mobile phase A, gradient elution was performed using acetonitrile as mobile phase B at a flow rate of 1.5ml per minute and a detection wavelength of 275nm. Take 5mg of Droperidol and 5mg of domperidone in a 100ml measuring flask, add lactic acid solution to dissolve and dilute to scale, shake well, take 20u1 and inject human liquid chromatograph, record chromatogram, the resolution between droperidol peak and domperidone peak should be greater than 3.5.
- measurement precision: take an appropriate amount of this product (about equivalent to droperidol lOmg), put it in a brown measuring flask, and dilute it with 1% lactic acid solution to make μl ml containing droperidol 0.1 mg of the solution, as a test solution, the precision of 20ul injection liquid chromatograph, record the chromatogram; Another precision weighing droperidol control about 10 mg, 100ml brown flask, add 1% lactic acid solution to dissolve and dilute to the scale, shake, and determine with the same method. According to the external standard method to calculate the peak area, that is.
category
Same as droperidol.
specification
(l)2ml:5mg (2)2ml:lOmg
storage
shade, close, and store in a cool place.
Last Update：2022-01-01 13:40:50
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Spot supply
Product Name: Droperidol Visit Supplier Webpage Request for quotationCAS: 548-73-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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