3-(1-Pyrrolidyl)-1-propanol

3-(1-Pyrrolidyl)-1-propanol - Names and Identifiers

Name	1-(3-hydroxypropyl)-Pyrrolidine
Synonyms	BRN 0103382 CHEMBRDG-BB 4012899 1-PYRROLIDINEPROPANOL 1-Pyrrolidinepropanol 3-(1-Pyrrolidyl)-1-propanol 3-(pyrrolidin-1-yl)propan-1-ol 1-(3-hydroxypropyl)-Pyrrolidine 1-(3-HYDROXYPROPYL)-PYRROLIDINE 4-20-00-00118 (Beilstein Handbook Reference)
CAS	19748-66-4
EINECS	1312995-182-4
InChI	InChI=1/C7H15NO/c9-7-3-6-8-4-1-2-5-8/h9H,1-7H2

3-(1-Pyrrolidyl)-1-propanol - Physico-chemical Properties

Molecular Formula	C7H15NO
Molar Mass	129.2
Density	0.983±0.06 g/cm3(Predicted)
Boling Point	98 °C(Press: 18 Torr)
Flash Point	97.7°C
Vapor Presure	0.0293mmHg at 25°C
pKa	15.02±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.482

3-(1-Pyrrolidyl)-1-propanol - Reference Information

use

1-(3-hydroxypropyl) pyrrolidine can be used as an intermediate in pharmaceutical and chemical synthesis.

Preparation

At 0°C, potassium carbonate (269g) and pyrrolidine (200mL) were sequentially added to the THF solution (500mL) of 3-bromopropanol (200g). After stirring the reaction solution at room temperature for 15 hours, ethyl acetate (500mL) was added and stirred for another 1 hour at room temperature. The resulting reaction solution was filtered with diatomite and the solids on the diatomite were washed with ethyl acetate. The washing liquid and filtrate were concentrated under reduced pressure, ethyl acetate (500mL) was added to the resulting residue, then stirred for 1 hour and filtered through diatomite. The filtrate was concentrated under reduced pressure, and the residue was purified by distillation (boiling point: 62°C, 1mmHg) to obtain 1-(3-hydroxypropyl) pyrrolidine (156g, yield 95%).

Last Update：2024-04-09 02:00:07