3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
2-Hydroxychalcone
CAS: 644-78-0
Molecular Formula: C15H12O2
3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one - Names and Identifiers
| Name | 2-Hydroxychalcone |
| Synonyms | 2-Hydroxychalcone 2-HYDROXYCHALCONE HYDROXYCHALCONE, 2- 2-(2-HYDROXYBENZAL)ACETOPHENONE BENZYLIDENE-2-HYDROXYACETOPHENONE 2-HYDROXYBENZYLIDENE ACETOPHENONE 2-(2-HYDROXYBENZYLIDENE)ACETOPHENONE 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one (E)-3-(2-HYDROXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE (2Z)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one (2-Hydroxybenzylidene)acetophenone~3-(2-Hydroxyphenyl)-1-phenyl-2-propen-1-one 2-Hydroxychalcone, [(2-Hydroxybenzylidene)- acetopheno |
| CAS | 644-78-0 |
| EINECS | 211-422-1 |
| InChI | InChI=1/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10- |
3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one - Physico-chemical Properties
| Molecular Formula | C15H12O2 |
| Molar Mass | 224.25 |
| Density | 1.191±0.06 g/cm3(Predicted) |
| Melting Point | 144-150°C(lit.) |
| Boling Point | 396.3±34.0 °C(Predicted) |
| Flash Point | 169.35°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Yellow powder. |
| BRN | 2049134 |
| pKa | 9.26±0.35(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Keep away from oxides. |
| Refractive Index | 1.654 |
| MDL | MFCD00016449 |
| In vitro study | 2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner. |
3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29147000 |
3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one - Reference
| Reference Show more | 1. Qian, Yun, et al. "2′-Hydroxychalcone Induced Cytotoxicity via Oxidative Stress in the Lipid-Loaded Hepg2 Cells." Frontiers in pharmacology 10 (2019): 1390.https://doi.org/10.3389/fphar.2019.01390 |
3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one - Reference Information
| biological activity | 2-hydroxychalcone is a natural flavonoid that is an antioxidant that inhibits lipid peroxidation. 2-hydroxychalcone induces apoptosis by down-regulating Bcl-2. 2-Hydroxychalcone inhibited activation by NF-kB. |
Last Update：2024-04-09 21:21:28
Supplier List
Spot supply
Product Name: 2-(2-Hydroxybenzal)Acetophenone Visit Supplier Webpage Request for quotationCAS: 644-78-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: 2-(2-Hydroxybenzal)Acetophenone Visit Supplier Webpage Request for quotationCAS: 644-78-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History